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Literature summary for 1.13.11.27 extracted from

  • Shan, C.; Lu, Z.; Li, Z.; Sheng, H.; Fan, J.; Qi, Q.; Liu, S.; Zhang, S.
    4-Hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis (2019), Cell Death Dis., 10, 525 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine HPD is highly expressed in lung cancer and expression correlates with poor prognosis in lung cancer patients. Suppressed HPD expression is sufficient to decrease oxidative pentose phosphate pathway flux, leading to reduced RNA biosynthesis and enhanced reactive oxygen species level, attenuated cancer cell proliferation, and tumor growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P32754
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Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
HPD
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 Homo sapiens

General Information

General Information Comment Organism
physiological function HPD promotes tyrosine catabolism leading to increased acetyl-CoA levels, the source of histone acetylation, and also stimulates histone deacetylase 10 translocation from the nucleus into the cytoplasm mediated by tumor suppressor liver kinase B1-AMP-activated protein kinase signaling Homo sapiens