Literature summary for 1.13.11.19 extracted from

Wang, Y.; Griffith, W.P.; Li, J.; Koto, T.; Wherritt, D.J.; Fritz, E.; Liu, A.
Cofactor biogenesis in cysteamine dioxygenase C-F bond cleavage with genetically incorporated unnatural tyrosine (2018), Angew. Chem. Int. Ed. Engl., 57, 8149-8153 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96SZ5	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	presence of a Cys-Tyr cofactor, crosslinked between Cys220 and Tyr222 through a thioether (C-S) bond	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ADO	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	presence of a Cys-Tyr cofactor, crosslinked between Cys220 and Tyr222 through a thioether (C-S) bond. An autocatalytic oxidative carbon-fluorine bond activation and fluoride release is observed. The crosslinking results in a minimal structural change of the protein. A sequence motif C-X-Y-Y(F) is proposed for identifying Cys-Tyr crosslink	Homo sapiens

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Release 2023.1 (January 2023)