Literature summary for 1.13.11.19 extracted from

Coloso Relicardo , C.R.; Hirschberger Lawrence , H.L.; Dominy John , D.J.; Lee Jeong-I, L.J.; Stipanuk Martha , S.M.
Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues (2006), Adv. Exp. Med. Biol., 583, 25-36.

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Protein Variants

Protein Variants	Comment	Organism
additional information	Vanin 1-/- and +/+ mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	(C57/B6), wild type and Vanin 1-/- and +/+ mice	-
Rattus norvegicus	-	Sprague-Dawley, rats switched from a high protein diet to a low protein diet or to a low protein diet supplemented with cysteamine do not demonstrate a change in tissue cysteamine dioxygenase activity over the course of 10 h.	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	Cysteamine levels in plasma of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have no markedly elevated levels of hypotaurine in plasma.	Rattus norvegicus	-
brain	Cysteamine levels in brain of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in brain.	Rattus norvegicus	-
brain	hypotaurine is not in brain of either Vanin-1 (+/+) or Vanin-1 (-/-) mice that had been fed a non-purified rodent diet.	Mus musculus	-
kidney	higher activity than in rat kidney. Hypotaurine is measurable in kidney, but levels are significantly higher in kidneys of the knock-out mice compared to wild-type mice.	Mus musculus	-
kidney	lower activity than in mice kidney. Cysteamine levels in kidney of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in kidney.	Rattus norvegicus	-
liver	higher activity than in rat liver. hypotaurine is not in liver of either Vanin-1 (+/+) or Vanin-1 (-/-) mice that had been fed a non-purified rodent diet.	Mus musculus	-
liver	lower activity than in mice liver. Cysteamine levels in liver of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in liver.	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000021	-	substrate: hypertaurine, kidney, activity is lower than in mice kidney	Rattus norvegicus
0.000026	-	substrate: hypertaurine, liver, activity is lower than in mice liver	Rattus norvegicus
0.000037	-	substrate: hypertaurine, kidney, higher activity in mice kidney than in rat kidney	Mus musculus
0.000062	-	substrate: hypertaurine, brain	Rattus norvegicus
0.000091	-	substrate: hypertaurine, liver, higher activity in mice liver than in rat liver	Mus musculus

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Release 2023.1 (January 2023)