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Literature summary for 1.13.11.19 extracted from

  • Richerson, R.B.; Ziegler, D.M.
    Cysteamine dioxygenase (1987), Methods Enzymol., 143, 410-415.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3-dithiopropane
-
Sus scrofa
1,4-dithiobutane
-
Sus scrofa
mercaptoethylguanidine noncompetitive to cysteamine Sus scrofa
pantetheine
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
cysteamine
-
Sus scrofa
0.1
-
O2
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Sus scrofa 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
2 * 64000, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8
-
-
Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, up to 3 years Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cysteamine + O2
-
Sus scrofa hypotaurine
-
?
additional information synthetic analogs of cysteamine oxidized: piperazinylcysteamine, N,N-dimethylcysteamine, trimethyl(2-mercaptoethyl)ammonium chloride, 2-mercaptoethanol, cysteine methyl ester Sus scrofa additional information
-
?
pantetheine + O2 oxidized at less than 3% of the cysteamine-dependent rate Sus scrofa pantothenate + cysteamine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 64000, SDS-PAGE Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.007
-
mercaptoethylguanidine
-
Sus scrofa
0.02
-
1,3-dithiopropane
-
Sus scrofa
0.02
-
1,4-dithiobutane
-
Sus scrofa