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Literature summary for 1.13.11.12 extracted from

  • Liu, S.H.; Shen, C.C.; Yi, Y.C.; Tsai, J.J.; Wang, C.C.; Chueh, J.T.; Lin, K.L.; Lee, T.C.; Pan, H.C.; Sheu, M.L.
    Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals (2010), Br. J. Pharmacol., 160, 1963-1972.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine induction of 15-LOX-1-mediated down-regulation of a PPAR-gamma and COX-2 pathway by honokiol is a therapeutic strategy for gastric cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
-
MKN-45 cell
-
Homo sapiens
-
NCI-N87 cell
-
Homo sapiens
-
SC-M1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linoleate + O2
-
Homo sapiens (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate primary product ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
-
Homo sapiens
15-LOX-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.04 mM honokiol markedly activates cellular 15-LOX-1 expression up