Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(allyloxy)phenyl benzoate | - |
Glycine max | |
4-allylphenyl benzoate | - |
Glycine max | |
estragol | - |
Glycine max | |
eugenol | - |
Glycine max | |
eugenyl benzoate | - |
Glycine max | |
methyleugenol | - |
Glycine max | |
additional information | 4-allyloxyaniline amides designed as inhibitors on the basis of eugenol and esteragol structures. Compounds are docked in SLO active site and fixed by hydrogen bonding with two conserved His513 and Gln716. Molecular volume of the amide moiety is a major factor in inhibitory potency variation of the synthetic amides, where the hydrogen bonding of the amide group can involve in the activity of the inhibitors | Glycine max | |
N1-(4-(allyloxy) phenyl)-1-admantancarboxamide | best inhibitor | Glycine max | |
N1-(4-(allyloxy) phenyl)-1-cyclobutanecarboxamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-1-cyclohexanecarboxamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-1-cyclopantanecarboxamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-1-cyclopropanecarboxamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-2-methylpropanamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-3-chlorobenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-3-fluorobenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-3-methoxybenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-3-methylbenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-4-chlorobenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-4-fluorobenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-4-methoxybenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)-4-methylbenzamide | - |
Glycine max | |
N1-(4-(allyloxy) phenyl)benzamide | - |
Glycine max |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | the allyloxy group of compounds is oriented towards the Fe(3+)-OH moiety in the active site of the enzyme | Glycine max |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Glycine max | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
linoleic acid + O2 | - |
Glycine max | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SLO | - |
Glycine max |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00067 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-1-admantancarboxamide | |
0.0022 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-1-cyclobutanecarboxamide | |
0.0033 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)benzamide | |
0.0038 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-4-fluorobenzamide | |
0.0041 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-1-cyclopantanecarboxamide | |
0.0056 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-3-fluorobenzamide | |
0.0061 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-1-cyclopropanecarboxamide | |
0.0062 | - |
pH 9.0, 20°C | Glycine max | 4-(allyloxy)phenyl benzoate | |
0.0064 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-1-cyclohexanecarboxamide | |
0.0067 | - |
pH 9.0, 20°C | Glycine max | 4-allylphenyl benzoate | |
0.0067 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-3-methylbenzamide | |
0.007 | - |
pH 9.0, 20°C | Glycine max | eugenyl benzoate | |
0.0081 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-3-chlorobenzamide | |
0.0088 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-4-chlorobenzamide | |
0.0101 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-4-methylbenzamide | |
0.0129 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-2-methylpropanamide | |
0.0138 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-4-methoxybenzamide | |
0.017 | - |
pH 9.0, 20°C | Glycine max | N1-(4-(allyloxy) phenyl)-3-methoxybenzamide | |
0.0382 | - |
pH 9.0, 20°C | Glycine max | eugenol | |
0.0641 | - |
pH 9.0, 20°C | Glycine max | estragol | |
0.0961 | - |
pH 9.0, 20°C | Glycine max | methyleugenol |