Crystallization (Comment) | Organism |
---|---|
in complex with an iron guanylyl pyridone, | Methanocaldococcus jannaschii |
Protein Variants | Comment | Organism |
---|---|---|
C250A | reduced activity | Methanocaldococcus jannaschii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO | CO is a competitive inhibitor with respect to H2 | Methanocaldococcus jannaschii | |
O2 | the enzyme is irreversibly inhibited under aerobic conditions | Methanocaldococcus jannaschii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanocaldococcus jannaschii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2 + methenyltetrahydromethanopterin | the heterolytic cleavage of H2 by the enzyme is dependent on the presence of methenyltetrahydromethanopterin | Methanocaldococcus jannaschii | H+ + methylenetetrahydromethanopterin | - |
r |
Synonyms | Comment | Organism |
---|---|---|
[Fe]-hydrogenase | - |
Methanocaldococcus jannaschii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
iron-sulfur centre | contains a mononuclear iron coordinated by the sulfur of cysteine 176, the iron center is the catalytically active constituent of an iron guanylyl pyridone cofactor | Methanocaldococcus jannaschii |