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Literature summary for 1.12.98.3 extracted from

  • Baumer, S.; Ide, T.; Jacobi, C.; Johann, A.; Gottschalk, G.; Deppenmeier, U.
    The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases (2000), J. Biol. Chem., 275, 17968-17973.
    View publication on PubMed
Search for more literature for 1.12.98.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Methanosarcina mazei

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound enzyme Methanosarcina mazei 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine Methanosarcina mazei coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate 2-dihydropentaprenyloxyphenazine
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 ?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine Methanosarcina mazei DSM 3647 coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate 2-dihydropentaprenyloxyphenazine
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 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina mazei Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1 Q8PU58: subunit A, F1SVL1: subunit C, Q8PZ67: subunit F, F1SVH7: subunit B, F1SVE4: subunit D, Q8PU59: subunit H, Q8PU60: subunit I, Q8PU61: subunit J, F1SVE0: subunit K, F1SVK0; subunit L, F1SVH9: subunit M, F1SVL2: subunit N, F1SVE1: subunit O
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Methanosarcina mazei DSM 3647 Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1 Q8PU58: subunit A, F1SVL1: subunit C, Q8PZ67: subunit F, F1SVH7: subunit B, F1SVE4: subunit D, Q8PU59: subunit H, Q8PU60: subunit I, Q8PU61: subunit J, F1SVE0: subunit K, F1SVK0; subunit L, F1SVH9: subunit M, F1SVL2: subunit N, F1SVE1: subunit O
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate Methanosarcina mazei 2-dihydropentaprenyloxyphenazine
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 ?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine cofactor F420(H2)-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred Methanosarcina mazei 2-dihydropentaprenyloxyphenazine
-
 ?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate Methanosarcina mazei DSM 3647 2-dihydropentaprenyloxyphenazine
-
 ?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine cofactor F420(H2)-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred Methanosarcina mazei DSM 3647 2-dihydropentaprenyloxyphenazine
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 ?

Cofactor

Cofactor Comment Organism Structure
coenzyme F420 the reaction is dependent on the cofactor F420 Methanosarcina mazei

General Information

General Information Comment Organism
physiological function the enzyme is part of the energy conserving electron transport system of the methanogenic archaeon Methanosarcina mazei Gö1 Methanosarcina mazei