Literature summary for 1.12.1.2 extracted from

Ohki, Y.; Yasumura, K.; Kuge, K.; Tanino, S.; Ando, M.; Li, Z.; Tatsumi, K.
Thiolate-bridged dinuclear iron(tris-carbonyl)-nickel complexes relevant to the active site of [NiFe] hydrogenase (2008), Proc. Natl. Acad. Sci. USA, 105, 7652-7657.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
CN-	-	synthetic construct
CO	-	synthetic construct
Fe	the (CO)3Fe(II) site is octahedral. An octahedral iron and a distorted square pyramidal nickel are linked by three bridging ligands	synthetic construct
Ni2+	take-up/release of substrates may occur at the Ni site. Flexible coordination structures at Ni may be responsible for the interconversion between H2 and (2H+) as the unique function of the [NiFe] hydrogenase. The coordination mode of the Ni(II) center can vary from square planar, to distorted square pyramidal, and to octahedral geometries, dependent on the nature of the ligands. An octahedral iron and a distorted square pyramidal nickel are linked by three bridging ligands	synthetic construct

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2 + acceptor	-	synthetic construct	H+ + reduced acceptor	-	?

Synonyms

Synonyms	Comment	Organism
[NiFe] hydrogenase	-	synthetic construct

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Release 2023.1 (January 2023)