BRENDA - Enzyme Database
show all sequences of 1.11.2.6

The genes ImbB1 and ImbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A

Neusser, D.; Schmidt, H.; Spizek, J.; Novotna, J.; Peschke, U.; Kaschabeck, S.; Tichy, P.; Piepersberg, W.; Arch. Microbiol. 169, 322-332 (1998)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli BL21 (DE3) cells
Streptomyces lincolnensis
Inhibitors
Inhibitors
Commentary
Organism
Structure
H2O2
-
Streptomyces lincolnensis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-tyrosine + H2O2
Streptomyces lincolnensis
-
L-dopa + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Streptomyces lincolnensis
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
Ni-NTA column chromatography
Streptomyces lincolnensis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-tyrosine + H2O2
-
755910
Streptomyces lincolnensis
L-dopa + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 38000, SDS-PAGE
Streptomyces lincolnensis
Synonyms
Synonyms
Commentary
Organism
L-tyrosine 3-hydroxylase
-
Streptomyces lincolnensis
LmbB2
-
Streptomyces lincolnensis
Cofactor
Cofactor
Commentary
Organism
Structure
heme b
-
Streptomyces lincolnensis
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21 (DE3) cells
Streptomyces lincolnensis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
heme b
-
Streptomyces lincolnensis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
H2O2
-
Streptomyces lincolnensis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-tyrosine + H2O2
Streptomyces lincolnensis
-
L-dopa + H2O
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
Ni-NTA column chromatography
Streptomyces lincolnensis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-tyrosine + H2O2
-
755910
Streptomyces lincolnensis
L-dopa + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 38000, SDS-PAGE
Streptomyces lincolnensis
Other publictions for EC 1.11.2.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755672
Wang
Biocatalytic carbon-hydrogen ...
Streptomyces lincolnensis
ACS Catal.
9
4764-4776
2019
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756033
Connor
A heme peroxidase with a func ...
Streptomyces refuineus
Biochemistry
50
8926-8936
2011
-
-
1
-
-
-
1
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
6
2
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
1
-
-
-
-
6
2
-
-
-
2
-
-
-
-
-
-
-
-
2
2
755910
Neusser
The genes ImbB1 and ImbB2 of ...
Streptomyces lincolnensis
Arch. Microbiol.
169
322-332
1998
-
-
1
-
-
-
1
-
-
-
-
1
-
5
-
-
1
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-