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Literature summary for 1.11.2.4 extracted from
- Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome P450s: kinetic deuterium isotope effects and analyses by resonance Raman spectroscopy (2002), Biochemistry, 41, 1886-1892.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Sphingomonas paucimobilis |
| expressed in Escherichia coli | Bacillus subtilis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.041 | - |
myristic acid | pH and temperature not specified in the publication | Sphingomonas paucimobilis |  |
| 0.058 | - |
myristic acid | pH and temperature not specified in the publication | Bacillus subtilis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Sphingomonas paucimobilis | P450BSbeta produces alpha- and beta-hydroxylated products at 33 and 67%, respectively | ? | - |
? | |
| additional information | Bacillus subtilis | P450BSbeta produces alpha- and beta-hydroxylated products at 33 and 67%, respectively | ? | - |
? | |
| additional information | Sphingomonas paucimobilis | P450SPalpha produces the alpha-hydroxylated products at 100% | ? | - |
? | |
| additional information | Bacillus subtilis | P450SPalpha produces the alpha-hydroxylated products at 100% | ? | - |
? | |
| myristic acid + H2O2 | Sphingomonas paucimobilis | - |
? | - |
? | |
| myristic acid + H2O2 | Bacillus subtilis | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | O31440 | - |
- |
| Sphingomonas paucimobilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-hydroxylauric acid + H2O2 | - |
Sphingomonas paucimobilis | ? | - |
? | |
| 2-hydroxylauric acid + H2O2 | - |
Bacillus subtilis | ? | - |
? | |
| additional information | P450BSbeta produces alpha- and beta-hydroxylated products at 33 and 67%, respectively | Sphingomonas paucimobilis | ? | - |
? | |
| additional information | P450BSbeta produces alpha- and beta-hydroxylated products at 33 and 67%, respectively | Bacillus subtilis | ? | - |
? | |
| additional information | P450SPalpha produces the alpha-hydroxylated products at 100% | Sphingomonas paucimobilis | ? | - |
? | |
| additional information | P450SPalpha produces the alpha-hydroxylated products at 100% | Bacillus subtilis | ? | - |
? | |
| myristic acid + H2O2 | - |
Sphingomonas paucimobilis | ? | - |
? | |
| myristic acid + H2O2 | - |
Bacillus subtilis | ? | - |
? | |
| myristic acid + H2O2 | - |
Sphingomonas paucimobilis | 2-hydroxy-myristic acid | - |
? | |
| myristic acid + H2O2 | - |
Bacillus subtilis | 2-hydroxy-myristic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP152A1 | - |
Bacillus subtilis |
| CYP152B1 | - |
Sphingomonas paucimobilis |
| hydrogen peroxide-dependent peroxygenase cytochrome P450 | - |
Sphingomonas paucimobilis |
| hydrogen peroxide-dependent peroxygenase cytochrome P450 | - |
Bacillus subtilis |
| P450BSbeta | - |
Bacillus subtilis |
| P450SPalpha | - |
Sphingomonas paucimobilis |
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