Literature summary for 1.11.2.2 extracted from

Soubhye, J.; Aldib, I.; Elfving, B.; Gelbcke, M.; Furtmueller, P.G.; Podrecca, M.; Conotte, R.; Colet, J.M.; Rousseau, A.; Reye, F.; Sarakbi, A.; Vanhaeverbeek, M.; Kauffmann, J.M.; Obinger, C.; Neve, J.; Prevost, M.; Zouaoui Boudjeltia, K.; Dufrasne, F.; Van Antwerpen, P.
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors (2013), J. Med. Chem., 56, 3943-3958.

Inhibitors

Inhibitors	Comment	Organism
4-(5-fluoro-1H-indol-3-yl)butanamide	reversible myeloperoxidase inhibitor, efficiently prevents enzyme-dependent LDL oxidation	Homo sapiens
4-(7-fluoro-1H-indol-3-yl)butanamide	-	Homo sapiens
5-(7-fluoro-1H-indol-3-yl)pentanamide	-	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P05164	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
low-density lipoprotein + Cl- + H2O2	-	Homo sapiens	? + H2O	enzyme produces oxidative modifications of the protein moiety of low density lipoproteins	?
taurine + Cl- + H2O2	-	Homo sapiens	taurine chloramine + H2O	-	?

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000018	-	low density lipoprotein oxidation, pH 7.2, 37°C	Homo sapiens	4-(5-fluoro-1H-indol-3-yl)butanamide
0.000018	-	taurine chlorination, pH 7.2, 37°C	Homo sapiens	4-(5-fluoro-1H-indol-3-yl)butanamide
0.000024	-	low density lipoprotein oxidation, pH 7.2, 37°C	Homo sapiens	4-(7-fluoro-1H-indol-3-yl)butanamide
0.000026	-	taurine chlorination, pH 7.2, 37°C	Homo sapiens	4-(7-fluoro-1H-indol-3-yl)butanamide
0.000034	-	taurine chlorination, pH 7.2, 37°C	Homo sapiens	5-(7-fluoro-1H-indol-3-yl)pentanamide
0.000044	-	low density lipoprotein oxidation, pH 7.2, 37°C	Homo sapiens	5-(7-fluoro-1H-indol-3-yl)pentanamide