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Literature summary for 1.11.2.2 extracted from

  • Zeraik, M.L.; Ximenes, V.F.; Regasini, L.O.; Dutra, L.A.; Silva, D.H.; Fonseca, L.M.; Coelho, D.; Machado, S.A.; Bolzani, V.S.
    4-Aminochalcones as novel inhibitors of the chlorinating activity of myeloperoxidase (2012), Curr. Med. Chem., 19, 5405-5413.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4'-amino-4-fluorochalcone potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM Homo sapiens
4'-amino-4-methylchalcone potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM Homo sapiens
4'-aminochalcone potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4'-amino-4-fluorochalcone
0.00025
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4'-amino-4-methylchalcone
0.000265
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4'-aminochalcone