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Literature summary for 1.11.2.2 extracted from

  • Panasenko, O.M.; Spalteholz, H.; Schiller, J.; Arnhold, J.
    Myeloperoxidase-induced formation of chlorohydrins and lysophospholipids from unsaturated phosphatidylcholines (2003), Free Radic. Biol. Med., 34, 553-562.
    View publication on PubMed
Search for more literature for 1.11.2.2

Inhibitors

Inhibitors Comment Organism Structure
Sodium azide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2
-
 Homo sapiens HClO + H2O
-
 ?
additional information in the presence of the complete MPO/H2O2/Cl- system, lyso-products and chlorohydrins are only formed at pH values lower than pH 6.0 with an optimum at pH 4.3 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
donor:hydrogen peroxide oxidoreductase
-
 Homo sapiens
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function hypochlorite formed by the MPO-H2O2-Cl- system is responsible for modification in unsaturated phosphatidylcholines (e.g. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2arachidonoyl-sn-glycero-3-phosphocholine, 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, or 1-palmitoyl-2-docosahexenoyl-sn-glycero-3-phosphocholine). The formation of lysophospholipids and chlorohydrins from unsaturated phosphatidylcholines by myeloperoxidase can be relevant in vivo under acute inflammatory conditions Homo sapiens