Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.2.2 extracted from

  • Jantschko, W.; Furtmueller, P.G.; Zederbauer, M.; Neugschwandtner, K.; Lehner, I.; Jakopitsch, C.; Arnhold, J.; Obinger, C.
    Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design (2005), Biochem. Pharmacol., 69, 1149-1157.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is an interesting target for anti-inflammatory therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-chlorotryptamine IC50: 0.00073 mM Homo sapiens
5-fluorotryptamine IC50: 0.00079 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
I- + H2O2 Homo sapiens myeloperoxidase plays a fundamental role in oxidant production by neutrophils ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-cyanoindole + H2O2
-
Homo sapiens ?
-
?
5-hydroxytryptamine + H2O2
-
Homo sapiens ?
-
?
5-nitroindole + H2O2
-
Homo sapiens ?
-
?
I- + H2O2
-
Homo sapiens ?
-
?
I- + H2O2 myeloperoxidase plays a fundamental role in oxidant production by neutrophils Homo sapiens ?
-
?
indole + H2O2
-
Homo sapiens ?
-
?
tryptamine + H2O2
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
myeloperoxidase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00073
-
IC50: 0.00073 mM Homo sapiens 5-chlorotryptamine
0.00079
-
IC50: 0.00079 mM Homo sapiens 5-fluorotryptamine