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Literature summary for 1.11.1.9 extracted from

  • Zheng, K.; Board, P.G.; Fei, X.; Sun, Y.; Lv, S.; Yan, G.; Liu, J.; Shen, J.; Luo, G.
    A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases (2008), Int. J. Biochem. Cell Biol., 40, 2090-2097.
    View publication on PubMed
Search for more literature for 1.11.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
S14A mutant shows reduced selenium content and strongly reduced glutathione peroxidase activity Homo sapiens
S15A mutant shows reduced selenium content and reduced glutathione peroxidase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.93
-
 GSH wild type enzyme, in the presence of 0.1 mM H2O2, at 37°C and pH 7.0 Homo sapiens
7.96
-
 GSH wild type enzyme, in the presence of 0.2 mM H2O2, at 37°C and pH 7.0 Homo sapiens
8.99
-
 H2O2 wild type enzyme, in the presence of 0.25 mM GSH, at 37°C and pH 7.0 Homo sapiens
9.87
-
 GSH wild type enzyme, in the presence of 0.5 mM H2O2, at 37°C and pH 7.0 Homo sapiens
11.1
-
 GSH wild type enzyme, in the presence of 1 mM H2O2, at 37°C and pH 7.0 Homo sapiens
12.6
-
 H2O2 wild type enzyme, in the presence of 0.5 mM GSH, at 37°C and pH 7.0 Homo sapiens
15.88
-
 H2O2 wild type enzyme, in the presence of 1 mM GSH, at 37°C and pH 7.0 Homo sapiens
19.08
-
 H2O2 wild type enzyme, in the presence of 2 mM GSH, at 37°C and pH 7.0 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenoenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens selenium containing glutathione transferase zeta1-1 does also possess glutathione peroxidase activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + GSH
-
 Homo sapiens H2O + GSSG
-
 ?
additional information selenium containing glutathione transferase zeta1-1 does also possess glutathione peroxidase activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GPX
-
 Homo sapiens
Se-hGSTZ1-1
-
 Homo sapiens
selenium containing glutathione transferase zeta1-1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
221.7
-
 GSH wild type enzyme, in the presence of 0.1 mM H2O2, at 37°C and pH 7.0 Homo sapiens
293.3
-
 GSH wild type enzyme, in the presence of 0.2 mM H2O2, at 37°C and pH 7.0 Homo sapiens
316.7
-
 H2O2 wild type enzyme, in the presence of 0.25 mM GSH, at 37°C and pH 7.0 Homo sapiens
361.7
-
 GSH wild type enzyme, in the presence of 0.5 mM H2O2, at 37°C and pH 7.0 Homo sapiens
408.3
-
 GSH wild type enzyme, in the presence of 1 mM H2O2, at 37°C and pH 7.0 Homo sapiens
445
-
 H2O2 wild type enzyme, in the presence of 0.5 mM GSH, at 37°C and pH 7.0 Homo sapiens
560
-
 H2O2 wild type enzyme, in the presence of 1 mM GSH, at 37°C and pH 7.0 Homo sapiens
670
-
 H2O2 wild type enzyme, in the presence of 2 mM GSH, at 37°C and pH 7.0 Homo sapiens