Literature summary for 1.11.1.9 extracted from

Ran, Q.; Liang, H.; Gu, M.; Qi, W.; Walter, C.A.; Roberts, L.J.2nd.; Herman, B.; Richardson, A.; Van Remmen, H.
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis (2004), J. Biol. Chem., 279, 55137-55146.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of Gpx4 in mice	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is uniquely involved in the detoxification of oxidative damage to membrane lipids. It plays a role in vivo in the mechanism of apoptosis induced by oxidative stress that most likely occurs through oxidative damage to mitochondrial phospholipids such as cardiolipin	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is uniquely involved in the detoxification of oxidative damage to membrane lipids. It plays a role in vivo in the mechanism of apoptosis induced by oxidative stress that most likely occurs through oxidative damage to mitochondrial phospholipids such as cardiolipin	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
glutathione peroxidase 4	-	Homo sapiens

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Release 2023.1 (January 2023)