Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.1.9 extracted from

  • Park, Y.S.; Koh, Y.H.; Takahashi, M.; Miyamoto, Y.; Suzuki, K.; Dohmae, N.; Takio, K.; Honke, K.; Taniguchi, N.
    Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185 (2003), Free Radic. Res., 37, 205-211.
    View publication on PubMed
Search for more literature for 1.11.1.9

Inhibitors

Inhibitors Comment Organism Structure
3-deoxyglucosone
-
 Bos taurus
Glyoxal
-
 Bos taurus
methylglyoxal Arg184 and Arg185, located in the glutathione binding site of the enzyme are irreversibly modified by treatment with methylglyoxal Bos taurus
additional information dicarbonyl compounds directly inactivate the enzyme, resulting in an increase in intracellular peroxides, which are responsible for oxidative cellular damage Bos taurus
Phenylglyoxal
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus major antioxidant enzyme ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major antioxidant enzyme Bos taurus ?
-
 ?
tert-butyl hydroperoxide + GSH
-
 Bos taurus tert-butyl alcohol + GSSG + H2O
-
 ?

Synonyms

Synonyms Comment Organism
GPX
-
 Bos taurus