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Literature summary for 1.11.1.8 extracted from
- Extrapolating in vitro screening assay data for thyroperoxidase inhibition to predict serum thyroid hormones in the rat (2020), Toxicol. Sci., 173, 280-292 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Methimazole | - |
Rattus norvegicus |  |
| propylthiouracil | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P14650 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thyroid gland | - |
Rattus norvegicus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | treatment of animals with inhibitors propylthiouracil or methimazole decreases thyroid hormone triiodothyronine and tetraiodothyronine levels in the thyroid gland and increases thyroid-stimulating hormone level. Less than 30% inhibition of TPO in vitro is sufficient to reduce serum tetraiodothyronine level by 20% | Rattus norvegicus |
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Release 2023.1 (January 2023)
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