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Literature summary for 1.11.1.8 extracted from
- Thyroid peroxidase activity is inhibited by phenolic compounds - impact of interaction (2019), Molecules, 24, 2766 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chlorogenic acid | noncompetitive | Sus scrofa |  |
| quercetin | uncompetitive, rutin and quercetin act additively | Sus scrofa | |
| rosmarinic acid | competitive, rutin and rosmarinic acid act additively | Sus scrofa | |
| rutin | competitive, rutin and quercetin as well as rutin and rosmarinic acid act additively | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | P09933 | - |
- |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.151 | - |
pH 7.4, 37°C | Sus scrofa | rosmarinic acid | |
| 0.267 | - |
pH 7.4, 37°C | Sus scrofa | chlorogenic acid | |
| 0.292 | - |
pH 7.4, 37°C | Sus scrofa | rutin | |
| 0.447 | - |
pH 7.4, 37°C | Sus scrofa | quercetin | |
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