Literature summary for 1.11.1.8 extracted from

Song, M.; Kim, Y.J.; Park, Y.K.; Ryu, J.C.
Changes in thyroid peroxidase activity in response to various chemicals (2012), J. Environ. Monit., 14, 2121-2126.

Search for more literature for 1.11.1.8

Activating Compound

Activating Compound	Comment	Organism	Structure
2,2'-dihydroxy-4-methoxy benzophenone	increases the enzyme activity by about 1.5fold	Homo sapiens
2,4-dihydroxy benzophenone	increases the enzyme activity by about 1.5fold	Homo sapiens
dibenzo(a,h)anthracene	2fold activation between 0.01 and 0.1 mM	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in FTC-238 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2',4,4'-tetrahydroxybenzophenone	inhibits enzyme activity by more than 60% from 0.00001 to 0.1 mM	Homo sapiens
3-methylcholanthrene	-	Homo sapiens
benzhydrol	reduces the enzyme activity by about 30% from 0.01 to 0.1 mM	Homo sapiens
benzo(e)pyrene	-	Homo sapiens
benzo(k)fluoranthene	-	Homo sapiens
benzophenone	-	Homo sapiens
genistein	inhibits enzyme activity by about 40% at 0.001 and 0.01 mM	Homo sapiens
heptachlor	weakly inhibits the enzyme activity by about 50% at 0.01 mM	Homo sapiens
Methimazole	enzyme activity is reduced by more than 70% by 0.1 and 1 mM	Homo sapiens
additional information	2,3,4-trihydroxybenzophenone, 2,4,4'-trihydroxybenzophenone, 4-hydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, chrysene, naphthalene, benzo(a)anthracene, phenanthrene, hexachlorobenzene, mirex, chlordane, and methylmercury have no effect on enzyme activity	Homo sapiens
perfluorooctane sulfonate	-	Homo sapiens
Perfluorooctanoic acid	slight inhibition at 0.01 mM	Homo sapiens
pyrene	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
thyroid epithelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guaiacol + H2O2 + H+	-	Homo sapiens	3,3'-dimethoxy-4,4'-biphenoquinone + H2O	-	?

Synonyms

Synonyms	Comment	Organism
thyroid peroxidase	-	Homo sapiens
thyroperoxidase	-	Homo sapiens
TPO	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme catalyzes the transfer of iodine to thyroglobulin during thyroid hormone synthesis	Homo sapiens

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Release 2023.1 (January 2023)