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Literature summary for 1.11.1.8 extracted from
- Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity (2009), J. Mol. Med., 87, 971-980.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CHO cells cultured in methimazole for days show a 58-82% reduction in high molecular weight-thyroid peroxidase isoforms at methimazole concentrations of 0.001-0.5 mM, whereas monomeric thyroid peroxidase expression is unchanged. A similar reduction in thyroid peroxidase expression (34-74%) is observed in CHO cells cultured in propylthiouracil (0.01-0.5 mM) | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
2 * 110000, SDS-PAGE | Homo sapiens |
| 220000 | 240000 | the high-molecular weight-thyroid peroxidase is in the 220000-240000 Da range, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 110000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high-molecular weight-thyroid peroxidase | - |
Homo sapiens |
| HMW-TPO | - |
Homo sapiens |
| thyroid peroxidase | - |
Homo sapiens |
| TPO | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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