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Literature summary for 1.11.1.8 extracted from

  • Masini-Repiso, A.M.; Bonaterra, M.; Spitale, L.; Di Fulvio, M.; Bonino, M.I.; Coleoni, A.H.; Orgnero-Gaisan, E.
    Ultrastructural localization of thyroid peroxidase, hydrogen peroxide-generating sites, and monoamine oxidase in benign and malignant thyroid diseases (2004), Hum. Pathol., 35, 436-446.
    View publication on PubMed
Search for more literature for 1.11.1.8

Localization

Localization Comment Organism GeneOntology No. Textmining
apical part of cell in Graves‘ disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive Homo sapiens 45177
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microvillus of Graves‘ disease thyroid, enzyme is absent in the microvilli in multinodular goiter Homo sapiens 5902
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mitochondrion Hashimoto‘s thyroiditis and oncocytic adenoma, are typically packed with mitochondria, display TPO reaction exclusivly in mitochondrial crisae Homo sapiens 5739
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additional information in the perinodular normal tissue the enzyme is absent in the apical surface, enzyme from multinodular goiter is absent in the microvilli Homo sapiens
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nuclear envelope in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles. In cells from Hashimoto‘s thyroiditis. In Graves‘ disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive Homo sapiens 5635
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rough endoplasmic reticulum in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles. In cells from Hashimoto‘s thyroiditis detected in scarce rough endoplasmic reticulum. In Graves‘ disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive Homo sapiens 5791
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vesicle in Graves' disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive, in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles Homo sapiens 31982
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens several changes in ultracytochemical characteristics of the enzyme are associated with thyroid disease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
additional information papillary carcinoma are negative for TPO Homo sapiens
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thyroid gland pathological tissue: Hashimoto‘s thyroiditis, Graves‘ disease, multinodular goiter, no activity in papillary carcinoma Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information several changes in ultracytochemical characteristics of the enzyme are associated with thyroid disease Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPO
-
 Homo sapiens