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Literature summary for 1.11.1.8 extracted from

  • Coval, M.L.; Taurog, A.
    Purification and iodinating activity of hog thyroid peroxidase (1967), J. Biol. Chem., 242, 5510-5523.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-Methyl-2-mercaptoimidazole competitive with iodide Sus scrofa
azide very effective Sus scrofa
glutathione
-
Sus scrofa
Iodide above 0.1 mM at pH 5, no inhibition at pH 7 Sus scrofa
p-Aminobenzoic acid
-
Sus scrofa
resorcinol
-
Sus scrofa
sulfathiazole
-
Sus scrofa
thiocyanate competitive with iodide Sus scrofa
thiouracil
-
Sus scrofa
Thiourea
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
I-
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
gel filtration, analytical ultracentrifugation Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
iodide + H2O2 Sus scrofa iodination and coupling reactions of proteins iodine + H2O
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
pig, female
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Sus scrofa
-
lymphoid tissue
-
Sus scrofa
-
additional information traces of activity in liver, kidney, heart, brain, ovary and muscle Sus scrofa
-
salivary gland
-
Sus scrofa
-
spleen
-
Sus scrofa
-
thyroid gland
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
32
-
purified enzyme Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, 6-12 months, no loss of activity Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
iodide + H2O2 highest activity if coupled with glucose-glucose oxidase reaction for H2O2 production Sus scrofa iodine + H2O
-
?
iodide + H2O2 iodination and coupling reactions of proteins Sus scrofa iodine + H2O
-
?

pH Range

pH Minimum pH Maximum Comment Organism
5 7 activity independent of pH Sus scrofa

Cofactor

Cofactor Comment Organism Structure
heme
-
Sus scrofa