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Literature summary for 1.11.1.7 extracted from
- Distinct enzyme-substrate interactions revealed by two dimensional kinetic comparison between dehaloperoxidase-hemoglobin and horseradish peroxidase (2015), J. Phys. Chem. B, 119, 12828-12837 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,4,6-tribromophenol | substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP; substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP | Amphitrite ornata |  |
| 2,4,6-Trichlorophenol | substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP; substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP | Amphitrite ornata | |
| additional information | no substrate inhibition by 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid); no substrate inhibition by 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | Amphitrite ornata | |
| additional information | enzyme does not exhibit any measurable substrate inhibition | Armoracia rusticana |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
H2O2 | 2,4,6-trichlorophenol, pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 0.025 | - |
H2O2 | 2,4,6-trichlorophenol, pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.029 | - |
H2O2 | 2,4,6-trichlorophenol, pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.05 | - |
H2O2 | cosubstrate 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid), pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 0.093 | - |
H2O2 | cosubstrate 2,4,6-tribromophenol, pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 0.141 | - |
H2O2 | cosubstrate 2,4,6-tribromophenol, pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.165 | - |
H2O2 | cosubstrate 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid), pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.212 | - |
H2O2 | cosubstrate 2,4,6-tribromophenol, pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.229 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.312 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.335 | - |
H2O2 | cosubstrate 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid), pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.448 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 0.685 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 1.02 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 2.07 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 4.53 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 5.1 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 5.4 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Amphitrite ornata | - |
- |
- |
| Amphitrite ornata | Q9NAV8 | isoform DHP A | - |
| Armoracia rusticana | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | isoform C | Armoracia rusticana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Armoracia rusticana | ? + H2O | - |
? | |
| 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Amphitrite ornata | ? + H2O | - |
? | |
| 2,4,6-tribromophenol + H2O2 | - |
Armoracia rusticana | ? + H2O | - |
? | |
| 2,4,6-tribromophenol + H2O2 | - |
Amphitrite ornata | ? + H2O | - |
? | |
| 2,4,6-trichlorophenol + H2O2 | - |
Armoracia rusticana | ? + H2O | - |
? | |
| 2,4,6-trichlorophenol + H2O2 | - |
Amphitrite ornata | ? + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dehaloperoxidase A | - |
Amphitrite ornata |
| dehaloperoxidase B | - |
Amphitrite ornata |
| DHP A | - |
Amphitrite ornata |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.7 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 1.05 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 1.83 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 1.87 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 13.67 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 25.72 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Amphitrite ornata | |
| 52.5 | - |
2,4,6-Trichlorophenol | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 223 | - |
2,4,6-tribromophenol | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
| 571 | - |
2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) | pH 7.0, temperature not specified in the publication | Armoracia rusticana | |
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