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Literature summary for 1.11.1.7 extracted from

  • Galzigna, L.; Rizzoli, V.; Schiappelli, M.P.; Rigobello, M.P.; Scarpa, M.; Rigo, A.
    Horseradish peroxidase-catalyzed sulfoxidation of promethazine and properties of promethazine sulfoxide (1996), Free Radic. Biol. Med., 20, 807-811.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ascorbic acid
-
Armoracia sp.
glutathione
-
Armoracia sp.
promethazine sulfoxide
-
Armoracia sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
H2O2 promethazine oxidation Armoracia sp.
0.11
-
Promethazine promethazine oxidation Armoracia sp.

Organism

Organism UniProt Comment Textmining
Armoracia sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information can also catalyze a reaction that results in the production of hydroxyl radicals from H2O2 in the presence of (O2)- radicals Armoracia sp. ?
-
?
promethazine + H2O2
-
Armoracia sp. promethazine sulfoxide + H2O
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.027
-
ascorbic acid promethazine oxidation Armoracia sp.
0.042
-
glutathione promethazine oxidation Armoracia sp.
0.06
-
promethazine sulfoxide promethazine oxidation Armoracia sp.