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Literature summary for 1.11.1.24 extracted from

  • Piacenza, L.; Peluffo, G.; Alvarez, M.N.; Kelly, J.M.; Wilkinson, S.R.; Radi, R.
    Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite (2008), Biochem. J., 410, 359-368.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
C52A parasites expressing CPX C52A fail to confer peroxynitrite resistance Trypanosoma cruzi
C81A parasites expressing MPX C81A fail to confer peroxynitrite resistance Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
H2O2
-
 Trypanosoma cruzi
peroxynitrite
-
 Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol CPX Trypanosoma cruzi 5829
-
mitochondrion MPX Trypanosoma cruzi 5739
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peroxynitrite + H2O2 CPX and MPX catalytically reduce peroxynitrite to nitrite through a fast-reacting thiol group located at the peroxidatic cysteine residue (Cys52 and Cys81 in CPX and MPX respectively), thus acting as tryparedoxin/peroxynitrite oxidoreductases Trypanosoma cruzi nitrite + ?
-
 ?

Synonyms

Synonyms Comment Organism
CPX belongs to the 2-cysteine peroxiredoxin family Trypanosoma cruzi
MPX
-
 Trypanosoma cruzi
tryparedoxin peroxidase
-
 Trypanosoma cruzi
tryparedoxin/peroxynitrite oxidoreductase
-
 Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.294
-
 MPX, at 28°C Trypanosoma cruzi H2O2
0.3
-
 CPX, at 28°C Trypanosoma cruzi H2O2
0.4
-
 MPX, at 28°C Trypanosoma cruzi peroxynitrite
0.48
-
 CPX, at 28°C Trypanosoma cruzi peroxynitrite