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Literature summary for 1.11.1.24 extracted from
- Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate (2000), J. Biol. Chem., 275, 20346-20354.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C152S | mutant enzyme shows no detectable thioredoxin-dependent peroxidase activity | Homo sapiens |
| C48S | mutant enzyme shows no detectable thioredoxin-dependent peroxidase activity | Homo sapiens |
| C73S | mutation has no effect on activity | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | the Km-value for H2O2 is below 0.02 mM | Homo sapiens | |
| 0.001 | - |
thioredoxin | pH 7.0, 37°C | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 17000 | - |
2 * 17000, SDS-PAGE | Homo sapiens |
| 17030 | - |
2 * 17030, calculation from nucleotide sequence | Homo sapiens |
| 34000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2O2 + reduced thioredoxin | - |
Homo sapiens | H2O + oxidized thioredoxin | - |
? | |
| additional information | no activity with glutaredoxin or glutathione | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 17000, SDS-PAGE | Homo sapiens |
| dimer | 2 * 17030, calculation from nucleotide sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PrxV | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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