Literature summary for 1.11.1.23 extracted from

Higgins, L.J.; Yan, F.; Liu, P.; Liu, H.W.; Drennan, C.L.
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme (2005), Nature, 437, 838-844.

Search for more literature for 1.11.1.23

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution	Streptomyces wedmorensis

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	mononuclear ioron	Streptomyces wedmorensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2	Streptomyces wedmorensis	-	cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+	i.e. fosfomycin	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces wedmorensis	Q56185	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2	-	Streptomyces wedmorensis	cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+	i.e. fosfomycin	?

Synonyms

Synonyms	Comment	Organism
HppE	-	Streptomyces wedmorensis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)