BRENDA - Reference to 1.11.1.23; Id = 705876

hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution

Streptomyces wedmorensis

Iron

mononuclear ioron

Streptomyces wedmorensis

(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2

Streptomyces wedmorensis

-

cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+

i.e. fosfomycin

-

?

Streptomyces wedmorensis

Q56185

-

(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2

-

705876

Streptomyces wedmorensis

cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+

i.e. fosfomycin

-

?

hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution

Streptomyces wedmorensis

Iron

mononuclear ioron

Streptomyces wedmorensis

(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2

Streptomyces wedmorensis

-

cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+

i.e. fosfomycin

-

?

(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2

-

705876

Streptomyces wedmorensis

cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+

i.e. fosfomycin

-

?

729898

Huang

Mechanistic consequences of ch ...

Streptomyces wedmorensis

J. Am. Chem. Soc.

136

2944-2947

2014

-

1

-

1

-

2

-

1

-

12

-

1

-

1

-

2

-

12

-

727328

Milaczewska

On the catalytic mechanism of ...

Streptomyces wedmorensis

Chemistry

19

771-781

2013

-

1

-

2

-

1

-

2

-

2

-

2

-

1

-

2

-

2

-

727696

Chang

Reaction of HppE with substrat ...

Streptomyces wedmorensis

J. Am. Chem. Soc.

135

8153-8156

2013

-

1

-

1

-

1

-

17

-

1

-

1

-

17

-

730966

Wang

Evidence that the fosfomycin-p ...

Yersinia pseudotuberculosis

Science

342

991-995

2013

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

727675

Huang

Evidence for radical-mediated ...

Streptomyces wedmorensis

J. Am. Chem. Soc.

134

16171-16174

2012

-

1

-

1

-

2

-

1

-

8

-

1

-

1

-

2

-

8

-

702244

Munos

Purification and characterizat ...

Pseudomonas syringae

Biochemistry

47

8726-8735

2008

-

1

-

1

-

1

3

1

-

3

-

1

-

3

1

-

1

-

2

-

1

2

-

1

-

1

3

1

-

1

-

3

1

-

1

-

702547

Schweifer

On the conversion of structura ...

Streptomyces fradiae

Bioorg. Med. Chem. Lett.

18

3056-3059

2008

-

1

-

1

-

1

-

3

-

1

-

1

-

3

-

702211

Yan

Determination of the substrate ...

Streptomyces wedmorensis

Biochemistry

46

12628-12638

2007

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

702208

Yan

Biosynthesis of fosfomycin, re ...

Streptomyces wedmorensis

Biochemistry

45

11473-11481

2006

-

1

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

701481

Cameron

Initiating a crystallographic ...

Streptomyces wedmorensis

Acta Crystallogr. Sect. F

61

534-536

2005

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

701900

Yan

Site-directed mutagenesis and ...

Streptomyces wedmorensis

Arch. Biochem. Biophys.

442

82-91

2005

-

1

-

3

-

1

-

2

-

1

-

2

-

1

2

-

3

-

1

-

1

-

705876

Higgins

Structural insight into antibi ...

Streptomyces wedmorensis

Nature

437

838-844

2005

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

706480

McLuskey

Structure and reactivity of hy ...

Streptomyces wedmorensis

Proc. Natl. Acad. Sci. USA

102

14221-14226

2005

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

704157

Liu

Oxygenase activity in the self ...

Streptomyces wedmorensis

J. Am. Chem. Soc.

126

10306-10312

2004

-

3

-

2

-

1

-

1

-

3

-

1

-

702205

Liu

Biochemical and spectroscopic ...

Streptomyces wedmorensis

Biochemistry

42

11577-11586

2003

-

1

-

1

-

1

3

1

-

1

-

1

-

1

-

3

-

1

3

-

1

-

1

3

1

-

1

-

1

-

701694

Zhao

Mechanistic studies of HPP epo ...

Streptomyces wedmorensis

Angew. Chem. Int. Ed. Engl.

41

4529-4532

2002

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

704155

Liu

Protein purification and funct ...

Streptomyces wedmorensis

J. Am. Chem. Soc.

123

4619-4620

2001

-

1

-

1

2

-

1

-

1

-

1

-

2

-

1

2

-

1

2

-

1

-

1

-

701777

Watanabe

A phosphonate-induced gene whi ...

Penicillium decumbens

Appl. Environ. Microbiol.

65

1036-1044

1999

-

1

-

702728

Kuzuyama

Cloning and expression in Esch ...

Pseudomonas syringae, Pseudomonas syringae PB-5123

Biosci. Biotechnol. Biochem.

63

2222-2224

1999

-

1

-

2

-

5

-

1

-

1

-

1

-

2

-

1

-

1

-

705742

Hidaka

Cloning and nucleotide sequenc ...

Streptomyces wedmorensis 144-91, Streptomyces wedmorensis

Mol. Gen. Genet.

249

274-280

1995

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme

Data extracted from this reference: