Data extracted from this reference:
Crystallization (Commentary)
hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution
Streptomyces wedmorensis
Metals/Ions
Iron
mononuclear ioron
Streptomyces wedmorensis
Natural Substrates/ Products (Substrates)
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2
Streptomyces wedmorensis
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+
i.e. fosfomycin
?
Organism
Streptomyces wedmorensis
Q56185
Substrates and Products (Substrate)
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2
705876
Streptomyces wedmorensis
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+
i.e. fosfomycin
?
Crystallization (Commentary) (protein specific)
hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution
Streptomyces wedmorensis
Metals/Ions (protein specific)
Iron
mononuclear ioron
Streptomyces wedmorensis
Natural Substrates/ Products (Substrates) (protein specific)
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2
Streptomyces wedmorensis
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+
i.e. fosfomycin
?
Substrates and Products (Substrate) (protein specific)
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2
705876
Streptomyces wedmorensis
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+
i.e. fosfomycin
?
Other publictions for EC 1.11.1.23
729898
Huang
Mechanistic consequences of ch ...
Streptomyces wedmorensis
J. Am. Chem. Soc.
136
2944-2947
2014
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727328
Milaczewska
On the catalytic mechanism of ...
Streptomyces wedmorensis
Chemistry
19
771-781
2013
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727696
Chang
Reaction of HppE with substrat ...
Streptomyces wedmorensis
J. Am. Chem. Soc.
135
8153-8156
2013
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730966
Wang
Evidence that the fosfomycin-p ...
Yersinia pseudotuberculosis
Science
342
991-995
2013
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727675
Huang
Evidence for radical-mediated ...
Streptomyces wedmorensis
J. Am. Chem. Soc.
134
16171-16174
2012
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702244
Munos
Purification and characterizat ...
Pseudomonas syringae
Biochemistry
47
8726-8735
2008
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702547
Schweifer
On the conversion of structura ...
Streptomyces fradiae
Bioorg. Med. Chem. Lett.
18
3056-3059
2008
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702211
Yan
Determination of the substrate ...
Streptomyces wedmorensis
Biochemistry
46
12628-12638
2007
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702208
Yan
Biosynthesis of fosfomycin, re ...
Streptomyces wedmorensis
Biochemistry
45
11473-11481
2006
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701481
Cameron
Initiating a crystallographic ...
Streptomyces wedmorensis
Acta Crystallogr. Sect. F
61
534-536
2005
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701900
Yan
Site-directed mutagenesis and ...
Streptomyces wedmorensis
Arch. Biochem. Biophys.
442
82-91
2005
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705876
Higgins
Structural insight into antibi ...
Streptomyces wedmorensis
Nature
437
838-844
2005
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706480
McLuskey
Structure and reactivity of hy ...
Streptomyces wedmorensis
Proc. Natl. Acad. Sci. USA
102
14221-14226
2005
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704157
Liu
Oxygenase activity in the self ...
Streptomyces wedmorensis
J. Am. Chem. Soc.
126
10306-10312
2004
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3
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702205
Liu
Biochemical and spectroscopic ...
Streptomyces wedmorensis
Biochemistry
42
11577-11586
2003
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701694
Zhao
Mechanistic studies of HPP epo ...
Streptomyces wedmorensis
Angew. Chem. Int. Ed. Engl.
41
4529-4532
2002
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704155
Liu
Protein purification and funct ...
Streptomyces wedmorensis
J. Am. Chem. Soc.
123
4619-4620
2001
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701777
Watanabe
A phosphonate-induced gene whi ...
Penicillium decumbens
Appl. Environ. Microbiol.
65
1036-1044
1999
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702728
Kuzuyama
Cloning and expression in Esch ...
Pseudomonas syringae, Pseudomonas syringae PB-5123
Biosci. Biotechnol. Biochem.
63
2222-2224
1999
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705742
Hidaka
Cloning and nucleotide sequenc ...
Streptomyces wedmorensis 144-91, Streptomyces wedmorensis
Mol. Gen. Genet.
249
274-280
1995
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