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Literature summary for 1.11.1.21 extracted from

  • Kapetanaki, S.M.; Chouchane, S.; Yu, S.; Zhao, X.; Magliozzo, R.S.; Schelvis, J.P.
    Mycobacterium tuberculosis KatG(S315T) catalase-peroxidase retains all active site properties for proper catalytic function (2005), Biochemistry, 44, 243-252.
    View publication on PubMed
Search for more literature for 1.11.1.21

Protein Variants

Protein Variants Comment Organism
S315T most prevalent isonazid-resistant mutant, determination of Fe2+-binding/interaction structure, minimal alterations compared to the wild-type enzyme, mutant enzyme retains all active site properties for proper catalytic function Mycobacterium tuberculosis
S315T isoniazid-resistant, mutant catalase-peroxidase retains all active site properties for proper catalytic function Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
CO complexed with the enzyme, structure determination, binding kinetics Mycobacterium tuberculosis
Fe2+ wild-type and S315T mutant enzyme, determination of Fe2+-binding/interaction structure Mycobacterium tuberculosis
NO complexed with the enzyme, structure determination, binding kinetics Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2O2 Mycobacterium tuberculosis
-
 O2 + H2O
-
 ?
isoniazid + H2O2 Mycobacterium tuberculosis activation of antituberculosis drug isonazid, catalytic mechanism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis
-
 enzyme KatG is a bifunctional
-

Reaction

Reaction Comment Organism Reaction ID
2 H2O2 = O2 + 2 H2O catalytic mechanism Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
isoniazid + H2O2
-
 Mycobacterium tuberculosis ?
-
 ?
isoniazid + H2O2 activation of antituberculosis drug isonazid, catalytic mechanism Mycobacterium tuberculosis ?
-
 ?

Synonyms

Synonyms Comment Organism
catalase-peroxidase
-
 Mycobacterium tuberculosis
catalase-peroxidase bifunctional enzyme with activities of EC 1.11.1.6 and EC 1.11.1.7 Mycobacterium tuberculosis
KatG
-
 Mycobacterium tuberculosis
KatG bifunctional enzyme with activities of EC 1.11.1.6 and EC 1.11.1.7 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
heme wild-type and S315T mutant enzyme, determination of Fe2+-binding/interaction structure Mycobacterium tuberculosis