BRENDA - Enzyme Database show
show all sequences of 1.11.1.20

Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Yoshikawa, K.; Takei, S.; Hasegawa-Ishii, S.; Chiba, Y.; Furukawa, A.; Kawamura, N.; Hosokawa, M.; Woodward, D.F.; Watanabe, K.; Shimada, A.; Brain Res. 1367, 22-32 (2011)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
Mus musculus
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
Mus musculus
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
?
thioredoxin + prostaglandin H2
Mus musculus
-
thioredoxin disulfide + prostaglandin F2alpha
-
-
?
thioredoxin + prostamide H2
Mus musculus
-
thioredoxin disulfide + prostamide F2alpha
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis
Mus musculus
-
central nervous system
prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies
Mus musculus
-
cerebellar cortex
-
Mus musculus
-
medulla oblongata
-
Mus musculus
-
myelin sheath
the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
oligodendrocyte
; cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
-
pons
-
Mus musculus
-
spinal cord
-
Mus musculus
-
white matter
there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
-
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
-
?
thioredoxin + prostaglandin H2
-
707934
Mus musculus
thioredoxin disulfide + prostaglandin F2alpha
-
-
-
?
thioredoxin + prostamide H2
-
707934
Mus musculus
thioredoxin disulfide + prostamide F2alpha
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
thioredoxin
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
thioredoxin
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
Mus musculus
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
Mus musculus
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
?
thioredoxin + prostaglandin H2
Mus musculus
-
thioredoxin disulfide + prostaglandin F2alpha
-
-
?
thioredoxin + prostamide H2
Mus musculus
-
thioredoxin disulfide + prostamide F2alpha
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis
Mus musculus
-
central nervous system
prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies
Mus musculus
-
cerebellar cortex
-
Mus musculus
-
medulla oblongata
-
Mus musculus
-
myelin sheath
the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
oligodendrocyte
; cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
-
pons
-
Mus musculus
-
spinal cord
-
Mus musculus
-
white matter
there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
-
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
-
?
thioredoxin + prostaglandin H2
-
707934
Mus musculus
thioredoxin disulfide + prostaglandin F2alpha
-
-
-
?
thioredoxin + prostamide H2
-
707934
Mus musculus
thioredoxin disulfide + prostamide F2alpha
-
-
-
?
Expression
Organism
Commentary
Expression
Mus musculus
the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles
up
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles
up
Other publictions for EC 1.11.1.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740108
Urquhart
Endocannabinoids and their oxy ...
Rattus norvegicus
Biochim. Biophys. Acta
1851
366-376
2015
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1
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743717
Iwasa
Prostaglandin F2alpha FP rece ...
Mus musculus
Prostaglandins Leukot. Essent. Fatty Acids
91
175-182
2014
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1
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1
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1
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740711
Silvestri
Anandamide-derived prostamide ...
Mus musculus
J. Biol. Chem.
288
23307-23321
2013
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1
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1
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1
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741103
Woodward
Recent progress in prostagland ...
Mus musculus
Pharmacol. Rev.
65
1135-1147
2013
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1
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1
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1
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1
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707934
Yoshikawa
Preferential localization of p ...
Mus musculus
Brain Res.
1367
22-32
2011
-
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-
-
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-
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1
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4
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1
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9
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4
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1
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4
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9
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4
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1
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1
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687797
Moriuchi
Molecular characterization of ...
Mus musculus, Sus scrofa
J. Biol. Chem.
283
792-801
2008
2
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1
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3
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1
12
2
1
3
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5
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2
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18
5
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15
2
2
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9
2
1
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1
1
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3
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12
2
1
3
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2
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18
5
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15
2
2
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9
2
1
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5
5