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Literature summary for 1.11.1.12 extracted from
- Phospholipid hydroperoxide glutathione peroxidase in bull spermatozoa provides a unique marker in the quest for semen quality analysis (2009), Theriogenology, 72, 91-98.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | an assay for sperm PHGPx activity emerges as a unique tool to evaluate semen quality for sire selection | Bos taurus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | - |
Bos taurus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + a lipid hydroperoxide | Bos taurus | - |
glutathione disulfide + lipid + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bull, three Italian beef breeds, Chianina, Marchigiana, Romagnola | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spermatozoon | - |
Bos taurus | - |
| testis | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.04 | - |
low-PHGPx group | Bos taurus |
| 0.0539 | - |
low-PHGPx, Chianina | Bos taurus |
| 0.056 | - |
low-PHGPx, Marchigiana | Bos taurus |
| 0.0746 | - |
low-PHGPx, Romagnola | Bos taurus |
| 0.13 | - |
high-PHGPx group | Bos taurus |
| 0.2242 | - |
high-PHGPx, Chianina | Bos taurus |
| 0.2447 | - |
high-PHGPx, Romagnola | Bos taurus |
| 0.2453 | - |
high-PHGPx, Marchigiana | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + a lipid hydroperoxide | - |
Bos taurus | glutathione disulfide + lipid + H2O | - |
? | |
| glutathione + phosphatidylcholine hydroperoxide | activity assay | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GPx4 | - |
Bos taurus |
| PHGPX | - |
Bos taurus |
| phospholipid hydroperoxide glutathione peroxidase | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
activity assay at room temperature | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
activity assay | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Bos taurus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bos taurus | PHGPx expression is up-regulated in spermatozoa by unknown mechanisms | up |
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Release 2023.1 (January 2023)
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