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Literature summary for 1.11.1.12 extracted from

  • Avery, A.M.; Avery, S.V.
    Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases (2001), J. Biol. Chem., 276, 33730-33735.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the triple deletion mutant gpx1delta/gpx2delta/gpx3delta is not growing with medium containing unsaturated linolenate Saccharomyces cerevisiae
wild-type enzyme gpx1, gpx2, gpx3 and mutants, expression in Escherichia coli Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information deletion mutants of gpx1delta, gpx2delta and gpx3delta showing diminished enzyme activity, triple mutant gpx1delta/gpx2delta/gpx3delta has almost no remaining activity Saccharomyces cerevisiae

General Stability

General Stability Organism
alpha-tocopherol stabilizes triple mutant against H2O2 and unsaturated linolenate Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + lipid hydroperoxide Saccharomyces cerevisiae protection of biomembranes against oxidative damage glutathione disulfide + lipid + H2O
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
genes GPX1, GPX2 and GPX3
-

Purification (Commentary)

Purification (Comment) Organism
wild-type and mutant proteins Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + lipid hydroperoxide
-
Saccharomyces cerevisiae glutathione disulfide + lipid + H2O
-
?
glutathione + lipid hydroperoxide protection of biomembranes against oxidative damage Saccharomyces cerevisiae glutathione disulfide + lipid + H2O
-
?