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Literature summary for 1.11.1.12 extracted from

  • Ursini, F.; Maiorino, M.; Valente, M.; Ferri, L.; Gregolin, C.
    Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides (1982), Biochim. Biophys. Acta, 710, 197-211.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + lipid hydroperoxide Sus scrofa protection of biomembranes against oxidative damage glutathione disulfide + lipid + H2O
-
?
additional information Sus scrofa enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.9
-
substrate tert-butyl hydroperoxide Sus scrofa
2.2
-
substrate phosphatidylcholine Sus scrofa
3.8
-
substrate cumene hydroperoxide Sus scrofa
107
-
purified enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + cumene hydroperoxide
-
Sus scrofa ?
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
-
Sus scrofa ?
-
?
glutathione + lipid hydroperoxide
-
Sus scrofa glutathione disulfide + lipid + H2O
-
?
glutathione + lipid hydroperoxide protection of biomembranes against oxidative damage Sus scrofa glutathione disulfide + lipid + H2O
-
?
glutathione + tert-butyl hydroperoxide
-
Sus scrofa ?
-
?
additional information enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 20000, SDS-PAGE Sus scrofa

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
complete loss of activity after 5 min Sus scrofa