Cloned (Comment) | Organism |
---|---|
expression of recombinant QR2 in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Melatonin | - |
Homo sapiens | |
additional information | inhibitor binding structures, overview | Homo sapiens | |
resveratrol | - |
Homo sapiens | |
S26695 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone | Homo sapiens | - |
1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | QR2 is overexpressed in neurodegenerative diseases | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone | - |
Homo sapiens | 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone | - |
? | |
additional information | quinone reductase 2 (QR2) is implicated in the reduction of quinone in the presence of natural derivatives of NADH such as N-ribosyldihydronicotinamide. QR2 does not recognize NADH or NADPH as co-substrates, unlike quinone reductase 1 (QR1) | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
quinone reductase 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoenzyme, binding structure, overview. 2 molecules per enzyme dimer, quantification, overview | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | specific inhibitors of QR2, tested in vivo, show outstanding properties impairing memory loss | Homo sapiens |
additional information | QR2 does not share many features with QR1. Particularly, it does not seem to have a similar detoxifying function in cells. QR2 is overexpressed in neurodegenerative diseases | Homo sapiens |