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Literature summary for 1.10.5.1 extracted from

  • Reybier, K.; Perio, P.; Ferry, G.; Bouajila, J.; Delagrange, P.; Boutin, J.A.; Nepveu, F.
    Insights into the redox cycle of human quinone reductase 2 (2011), Free Radic. Res., 45, 1184-1195.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged OR2 in Spodoptera frugiperda Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol
-
Homo sapiens
Melatonin
-
Homo sapiens
resveratrol
-
Homo sapiens
S29434 synthetic compound, complete inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q Homo sapiens natural substrate nicotinamide riboside, NRH 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
-
?
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + menadione Homo sapiens natural substrate nicotinamide riboside, NRH 1-(beta-D-ribofuranosyl)nicotinamide + menadiol
-
?
additional information Homo sapiens the enzyme catalyzes the reduction of quinones, such as menadione and co-enzyme Q ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged OR2 from Spodoptera frugiperda Sf9 cells by nickel affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
?
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q natural substrate nicotinamide riboside, NRH Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
-
?
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + menadione natural substrate nicotinamide riboside, NRH Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + menadiol
-
?
additional information the enzyme catalyzes the reduction of quinones, such as menadione and co-enzyme Q Homo sapiens ?
-
?
additional information QR2 produces free radicals with pro-drug CB1954, i.e. 5-(aziridin-1-yl)-2,4-dinitrobenzamide. The anti-cancer pro-drug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) is transformed into a potent cytotoxic drug upon reduction of its 4-nitro group to a 4-hydroxylamine by quinone reductases or nitroreductase Homo sapiens ?
-
?
N-benzyldihydronicotinamide + a quinone synthetic substrate Homo sapiens N-benzylnicotinamide + a hydroquinone
-
?

Subunits

Subunits Comment Organism
homodimer the enzyme forms homodimers with two independent and equivalent active sites each containing a FAD cofactor Homo sapiens

Synonyms

Synonyms Comment Organism
NRH:QR2
-
Homo sapiens
QR2
-
Homo sapiens
quinone reductase 2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD 1 molecule per subunit, binds to the active site of each subunit Homo sapiens

General Information

General Information Comment Organism
additional information comparison of isoenzymes Qr1 and QR2, overview Homo sapiens