Literature summary for 1.10.5.1 extracted from

Benoit, C.E.; Bastianetto, S.; Brouillette, J.; Tse, Y.; Boutin, J.A.; Delagrange, P.; Wong, T.; Sarret, P.; Quirion, R.
Loss of quinone reductase 2 function selectively facilitates learning behaviors (2010), J. Neurosci., 30, 12690-12700.

Search for more literature for 1.10.5.1

Application

Application	Comment	Organism
medicine	QR2 inhibitors possibly represent a therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 insect cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
S26695	selective inhibitor of QR2	Rattus norvegicus
S29434	selective inhibitor of QR2	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain cortex	-	Rattus norvegicus	-
embryonic hippocampal cell line	-	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-benzyldihydronicotinamide + menadione	-	Rattus norvegicus	N-benzylnicotamide + menadiol	-	?

Synonyms

Synonyms	Comment	Organism
QR2	-	Rattus norvegicus
quinone reductase 2	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	adult QR2 knock-out mice demonstrate enhanced learning abilities in various tasks, including Morris water maze, object recognition, and rotarod performance test, while other behaviors related to anxiety (elevated plus maze), depression (forced swim), and schizophrenia (prepulse inhibition) are not affected in QR2-deficient mice. QR2 inhibition protects hippocampal cells against menadione-induced toxicity and serum deprivation and can reverse cognitive deficits	Rattus norvegicus
physiological function	QR2 plays a role in cognitive behaviors	Rattus norvegicus

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Release 2023.1 (January 2023)