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Literature summary for 1.10.5.1 extracted from

  • Cai, J.B.; Zhang, Z.H.; Xu, D.J.; Qian, Z.Y.; Wang, Z.R.; Huang, Y.Z.; Zou, J.G.; Cao, K.J.
    Negative regulation of quinone reductase 2 by resveratrol in cultured vascular smooth muscle cells (2008), Clin. Exp. Pharmacol. Physiol., 35, 1419-1425.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus quinone reductase 2 is a target of resveratrol in vascular smooth muscle cells. Resveratrol reduces quinone reductase protein levels and suppresses quinone reductase 2 mRNA expression in cultured vascular smooth muscle cell. The inhibition of vascular smooth muscle cell proliferation by resveratrol is effected via the negative regulation of quinone reductase 2. Quinone reductase 2 may be the main target for resveratrol and may be used to mediate the potential therapeutic role of resveratrol in atherosclerosis and restenosis after injury ?
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell suppression of vascular smooth muscle cell proliferation mediated by resveratrol correlates with vascular smooth muscle cell downregulation Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information quinone reductase 2 is a target of resveratrol in vascular smooth muscle cells. Resveratrol reduces quinone reductase protein levels and suppresses quinone reductase 2 mRNA expression in cultured vascular smooth muscle cell. The inhibition of vascular smooth muscle cell proliferation by resveratrol is effected via the negative regulation of quinone reductase 2. Quinone reductase 2 may be the main target for resveratrol and may be used to mediate the potential therapeutic role of resveratrol in atherosclerosis and restenosis after injury Oryctolagus cuniculus ?
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Synonyms

Synonyms Comment Organism
NQO2
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Oryctolagus cuniculus
quinone reductase 2
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Oryctolagus cuniculus