BRENDA - Enzyme Database show
show all sequences of 1.10.5.1

Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954

Fu, Y.; Buryanovskyy, L.; Zhang, Z.; Biochem. Biophys. Res. Commun. 336, 332-338 (2005)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
anti-cancer therapy
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
-
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
N161H
results in the total loss of the enzymatic activity towards activation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide, whereas the rates of reduction towards menadione are not altered
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.061
-
5-(aziridin-1-yl)-2,4-dinitrobenzamide
at 25°C in pH 8.5 buffer (50 mM Tris, 140 mM NaCl, and 0.1% Tween 20) with 0.1 mM menadione as co-substrate
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
DEAE Sepharose, Superdex 75 column chromatography and Mono-Q column chromatography
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-(aziridin-1-yl)-2,4-dinitrobenzamide + menadiol
-
671708
Homo sapiens
? + reduced menadiol
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
6
-
5-(aziridin-1-yl)-2,4-dinitrobenzamide
at 25°C in pH 8.5 buffer (50 mM Tris, 140 mM NaCl, and 0.1% Tween 20) with 0.1 mM menadione as co-substrate
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
anti-cancer therapy
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
N161H
results in the total loss of the enzymatic activity towards activation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide, whereas the rates of reduction towards menadione are not altered
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.061
-
5-(aziridin-1-yl)-2,4-dinitrobenzamide
at 25°C in pH 8.5 buffer (50 mM Tris, 140 mM NaCl, and 0.1% Tween 20) with 0.1 mM menadione as co-substrate
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE Sepharose, Superdex 75 column chromatography and Mono-Q column chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-(aziridin-1-yl)-2,4-dinitrobenzamide + menadiol
-
671708
Homo sapiens
? + reduced menadiol
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
6
-
5-(aziridin-1-yl)-2,4-dinitrobenzamide
at 25°C in pH 8.5 buffer (50 mM Tris, 140 mM NaCl, and 0.1% Tween 20) with 0.1 mM menadione as co-substrate
Homo sapiens
Other publictions for EC 1.10.5.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742815
Riches
The ontogeny and population v ...
Homo sapiens
J. Biochem. Mol. Toxicol.
31
0000
2017
-
-
-
-
-
-
1
-
1
-
-
1
-
2
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724559
John
Design, synthesis, biological ...
Homo sapiens
Bioorg. Med. Chem.
21
6022-6037
2013
-
-
1
1
-
-
34
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
34
1
1
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
725512
Leung
Chloroquine binding reveals fl ...
Homo sapiens
J. Biol. Chem.
288
11242-11251
2013
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725158
Antoine
-
Characterization of cofactors, ...
Homo sapiens
Int. J. Mass Spectrom.
312
87-96
2012
-
-
1
-
-
-
4
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
725669
Michaelis
Dabigatran and dabigatran ethy ...
Homo sapiens
J. Med. Chem.
55
3934-3944
2012
-
-
-
-
-
-
17
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
3
-
2
-
-
-
1
-
-
-
2
17
3
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724751
Dufour
Mechanism-based inhibition of ...
Homo sapiens
ChemBioChem
12
1203-1208
2011
-
-
-
-
-
-
12
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
12
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725071
Reybier
Insights into the redox cycle ...
Homo sapiens
Free Radic. Res.
45
1184-1195
2011
-
-
1
-
-
-
4
-
1
-
-
3
-
3
-
-
1
-
-
-
-
-
6
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
1
-
-
3
-
-
-
1
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
711408
Nolan
Imidazoacridin-6-ones as novel ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
2832-2836
2010
-
-
-
-
-
-
34
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34
-
-
-
-
-
-
-
34
34
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711432
Nolan
In silico identification and b ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
7331-7336
2010
-
-
-
-
-
-
44
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
37
-
-
-
1
-
-
-
37
44
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711470
Nolan
Triazoloacridin-6-ones as nove ...
Homo sapiens
Bioorg. Med. Chem.
18
696-706
2010
-
-
-
-
-
-
15
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
15
-
-
-
1
-
-
-
15
15
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711729
Ferry
Old and new inhibitors of quin ...
Homo sapiens
Chem. Biol. Interact.
186
103-109
2010
-
-
1
-
-
-
6
10
1
-
-
-
-
1
-
-
1
-
-
-
-
-
11
-
-
-
-
-
-
-
-
1
-
-
19
-
-
1
1
-
-
-
19
6
-
10
1
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712829
Benoit
Loss of quinone reductase 2 fu ...
Rattus norvegicus
J. Neurosci.
30
12690-12700
2010
-
1
1
-
-
-
2
-
1
-
-
-
-
6
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
697007
Winger
The structure of the leukemia ...
Homo sapiens
BMC Struct. Biol.
9
7
2009
-
-
1
1
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
698051
Gaikwad
Evidence for NQO2-mediated red ...
Homo sapiens
Free Radic. Biol. Med.
46
253-262
2009
-
1
-
-
-
-
2
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
2
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699456
Maiti
Synthesis of casimiroin and op ...
Homo sapiens
J. Med. Chem.
52
1873-1884
2009
-
-
-
1
-
-
19
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
1
-
-
18
19
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688130
Wang
Association of NRH:quinone oxi ...
Homo sapiens
J. Gerontol. A Biol. Sci. Med. Sci.
63
127-134
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695860
Boutin
Studies of the melatonin bindi ...
Homo sapiens
Arch. Biochem. Biophys.
477
12-19
2008
-
-
1
-
10
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
696093
Calamini
Kinetic, thermodynamic and X-r ...
Homo sapiens
Biochem. J.
413
81-91
2008
-
-
1
1
-
-
5
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
2
-
5
-
-
1
-
1
-
-
5
5
2
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
697413
Cai
Negative regulation of quinone ...
Oryctolagus cuniculus
Clin. Exp. Pharmacol. Physiol.
35
1419-1425
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698793
Fu
Quinone reductase 2 is a catec ...
Rattus norvegicus
J. Biol. Chem.
283
23829-23835
2008
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686136
Jamieson
NAD(P)H:quinone oxidoreductase ...
Homo sapiens
Clin. Cancer Res.
13
1584-1590
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671921
Celli
NRH:quinone oxidoreductase 2 ( ...
Mus musculus
Biochem. Pharmacol.
72
366-376
2006
-
-
1
-
-
-
3
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673791
Wang
Nulear factor Nrf2 and antioxi ...
Homo sapiens
Free Radic. Biol. Med.
40
1119-1130
2006
-
-
1
-
-
-
2
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674664
Iskander
NQO1 and NQO2 regulation of hu ...
Mus musculus
J. Biol. Chem.
281
30917-30924
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657888
Vella
NRH:quinone reductase 2: an en ...
Homo sapiens, Mus musculus
Biochem. Pharmacol.
71
1-12
2005
-
-
-
1
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
9
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
9
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657889
Mailliet
Characterization of the melato ...
Homo sapiens
Biochem. Pharmacol.
71
74-88
2005
-
-
-
-
-
-
17
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
11
-
16
-
-
-
-
-
-
-
16
17
11
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658434
Boutin
Quinone reductase 2 substrate ...
Homo sapiens
Chem. Biol. Interact.
151
213-228
2005
-
-
-
-
-
-
10
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
9
-
-
-
1
-
-
-
9
10
-
3
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671708
Fu
Crystal structure of quinone r ...
Homo sapiens
Biochem. Biophys. Res. Commun.
336
332-338
2005
-
1
1
1
1
-
-
1
-
1
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
1
1
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
676176
Okada
No associations between Parkin ...
Homo sapiens
Neurosci. Lett.
375
178-180
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658023
Buryanovskyy
Crystal structure of quinone r ...
Homo sapiens
Biochemistry
43
11417-11426
2004
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
1
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658749
Mailliet
Organs from mice deleted for N ...
Mus musculus
FEBS Lett.
578
116-120
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659967
Strassburg
Differential gene expression o ...
Homo sapiens
Mol. Pharmacol.
61
320-325
2002
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659968
Graves
Discovery of novel targets of ...
Homo sapiens
Mol. Pharmacol.
62
1364-1372
2002
-
-
-
-
-
-
5
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658430
Long
NRH:quinone oxidoreductase2 (N ...
Homo sapiens
Chem. Biol. Interact.
129
99-112
2000
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658817
Long
Mouse NRH:quinone oxidoreducta ...
Mus musculus
Gene
252
107-117
2000
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659146
Nosjean
Identification of the melatoni ...
Homo sapiens, Mesocricetus auratus
J. Biol. Chem.
275
31311-31317
2000
-
-
1
-
-
-
13
4
-
-
-
2
-
5
-
-
2
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
13
-
-
-
-
1
-
-
-
-
-
13
13
4
-
-
-
2
-
-
-
2
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394377
Wu
Catalytic properties of NAD(P) ...
Homo sapiens
Arch. Biochem. Biophys.
347
221-228
1997
-
-
-
-
1
-
14
8
-
-
2
-
-
1
-
-
1
-
-
-
-
-
6
1
-
-
-
8
-
-
-
2
1
-
-
-
-
-
2
-
1
-
-
14
1
8
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
8
-
-
-
-
-
-
-
-
-
-
660397
Zhao
Unexpected genetic and structu ...
Bos taurus, Homo sapiens
Proc. Natl. Acad. Sci. USA
94
1669-1674
1997
-
-
1
-
-
-
2
-
-
-
2
-
-
5
-
-
1
-
-
2
1
-
2
2
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
-
-
-
2
-
-
-
-
2
-
-
-
-
1
-
2
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659111
Liao
Purification and properties of ...
Bos taurus, Rattus norvegicus
J. Biol. Chem.
237
2981-2987
1962
-
-
-
-
-
-
7
2
-
-
-
-
-
2
-
-
1
-
-
10
1
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
7
-
2
-
-
-
-
-
-
-
1
-
10
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-