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Literature summary for 1.10.5.1 extracted from

  • Nosjean, O.; Ferro, M.; Coge, F.; Beauverger, P.; et al.
    Identification of the melatonin-binding site MT3 as the quinone reductase 2 (2000), J. Biol. Chem., 275, 31311-31317.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-iodomelatonin
-
Homo sapiens
2-iodomelatonin
-
Mesocricetus auratus
5-methoxycarbonylamino-N-acetyltryptamine
-
Homo sapiens
5-methoxycarbonylamino-N-acetyltryptamine
-
Mesocricetus auratus
dicoumarol
-
Homo sapiens
dicoumarol
-
Mesocricetus auratus
Melatonin
-
Homo sapiens
Melatonin
-
Mesocricetus auratus
N-acetylserotonin
-
Homo sapiens
N-acetylserotonin
-
Mesocricetus auratus
S26553
-
Homo sapiens
S26553 i.e. N-methyl-[1-[2-(acetylamino)ethyl]naphthalen-7-yl]-carbamate Mesocricetus auratus
serotonin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0089
-
menadione pH 7.5 Homo sapiens
0.0252
-
menadione pH 7.5 Mesocricetus auratus
0.0576
-
dihydrobenzylnicotinamide pH 7.5 Homo sapiens
0.0608
-
dihydrobenzylnicotinamide pH 7.5 Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme exhibits melatonin-binding activity ?
-
?
additional information Mesocricetus auratus enzyme exhibits melatonin-binding activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
expressed in CHO cells
-
Mesocricetus auratus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
kidney
-
Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + dihydrobenzylnicotinamide
-
Homo sapiens ?
-
?
menadione + dihydrobenzylnicotinamide
-
Mesocricetus auratus ?
-
?
additional information enzyme exhibits melatonin-binding activity Homo sapiens ?
-
?
additional information enzyme exhibits melatonin-binding activity Mesocricetus auratus ?
-
?

Synonyms

Synonyms Comment Organism
melatonin-binding site MT3
-
Homo sapiens
melatonin-binding site MT3
-
Mesocricetus auratus
QR2
-
Homo sapiens
quinone reductase 2
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
2-iodomelatonin pH 7.5 Mesocricetus auratus
0.0028
-
S26553 pH 7.5 Mesocricetus auratus
0.029
-
2-iodomelatonin pH 7.5 Homo sapiens
0.0414
-
S26553 pH 7.5 Homo sapiens
0.043
-
Melatonin pH 7.5 Mesocricetus auratus
0.0435
-
5-methoxycarbonylamino-N-acetyltryptamine pH 7.5 Mesocricetus auratus
0.092
-
N-acetylserotonin pH 7.5 Mesocricetus auratus
0.204
-
N-acetylserotonin pH 7.5 Homo sapiens
0.246
-
Melatonin pH 7.5 Homo sapiens
0.376
-
5-methoxycarbonylamino-N-acetyltryptamine pH 7.5 Homo sapiens
0.566
-
dicoumarol pH 7.5 Mesocricetus auratus
0.62
-
dicoumarol pH 7.5 Homo sapiens
2.933
-
serotonin
-
Homo sapiens