Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-dimethylphenanthrene | 0.00001 mM, 15% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
12-methylbenz[a]anthracene | 0.00001 mM, 51% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
7,12-dimethylbenz[a]anthracene | 0.00001 mM, 51% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
7-methylbenz[a]anthracene | 0.00001 mM, 66% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
9,10-dimethylanthracene | 0.00001 mM, 25% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
9-methylanthracene | 0.00001 mM, 26% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus | |
benz[a]anthracene | 0.00001 mM, 40% inhibition of the reaction with N1-(n-propyl)-nicotinamide | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
menadione | pH 7.6, with reduced N1-(n-propyl)-nicotinamide as acceptor | Bos taurus | |
0.023 | - |
reduced N1-(n-propyl)-nicotinamide | pH 7.6 | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
erythrocyte | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Bos taurus | - |
liver | - |
Rattus norvegicus | - |
additional information | no activity in blood plasma | Rattus norvegicus | - |
prostate gland ventral lobe | - |
Rattus norvegicus | - |
seminal vesicle | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydronicotinamide riboside + menadione | - |
Bos taurus | ribosyl nicotinamide + menadiol | - |
? | |
additional information | no activity with NADH, NADPH, NMNH, reduced 3-acetylpyridine adenine dinucleotide, xanthine or hypoxanthine. No activity with 1,4-benzoquinone and potassium ferricyanide | Bos taurus | ? | - |
? | |
reduced N1-(benzyl)-nicotinamide + menadione | - |
Bos taurus | N1-(benzyl)-nicotinamide + menadiol | - |
? | |
reduced N1-(methyl)-nicotinamide + menadione | - |
Bos taurus | N1-(methyl)-nicotinamide + reduced menadiol | - |
? | |
reduced N1-(n-propyl)-nicotinamide + menadione | - |
Bos taurus | N1-(n-propyl)-nicotinamide + menadiol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-ribosyldihydronicotinamide dehydrogenase (quinone) | - |
Bos taurus |
NQO2 | - |
Rattus norvegicus |
NQO2 | - |
Bos taurus |
NRH-oxidizing enzyme | - |
Bos taurus |
NRH:quinone oxidoreductase 2 | - |
Rattus norvegicus |
NRH:quinone oxidoreductase 2 | - |
Bos taurus |
QR2 | - |
Bos taurus |
quinone reductase 2 | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | the enzyme contains FAD as the sole bound flavin. The prosthetic group can be removed by treatment with acid in ammonium sulfate, and the resolved enzyme may be reactivated by FAD or by higher concentrations FMN | Bos taurus | |
FMN | the enzyme contains FAD as the sole bound flavin. The prosthetic group can be removed by treatment with acid in ammonium sulfate, and the resolved enzyme may be reactivated by FAD or by higher concentrations FMN | Bos taurus |