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Literature summary for 1.10.5.1 extracted from

  • Buryanovskyy, L.; Fu, Y.; Boyd, M.; Ma, Y.; Hsieh, T.; Wu, J.M.; Zhang, Z.
    Crystal structure of quinone reductase 2 in complex with resveratrol (2004), Biochemistry, 43, 11417-11426.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the enzyme in complex with resveratrol. Crystals of the native QR2 and QR2-resveratrol complex all belong to the P2(1)2(1)2(1) space group Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
resveratrol the chemopreventive and cardioprotective properties of resveratrol are possibly the results of QR2 activity inhibition, which in turn, up-regulates the expression of cellular antioxidant enzymes and cellular resistance to oxidative stress. All three resveratrol hydroxyl groups form hydrogen bonds with amino acids from QR2, anchoring a flat resveratrol molecule in parallel with the isoalloxazine ring of FAD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens knockdown K562 cells exhibit increased antioxidant and detoxification enzyme expression and reduced proliferation rates ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16083 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + 1-(2-hydroxyethyl)dihydronicotinamide
-
Homo sapiens ?
-
?
additional information knockdown K562 cells exhibit increased antioxidant and detoxification enzyme expression and reduced proliferation rates Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
QR2
-
Homo sapiens
quinone reductase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
resveratrol
-
Homo sapiens