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Literature summary for 1.10.5.1 extracted from

  • Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J.A.
    NRH:quinone reductase 2: an enzyme of surprises and mysteries (2005), Biochem. Pharmacol., 71, 1-12.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
2.1 A resolution Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis ?
-
?
additional information Homo sapiens high QR2 activity might make individuals more susceptible to Parkinson‘s disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16083 comparison with quinone reductase 1
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain minimal expression Homo sapiens
-
erythrocyte modest level Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver high expression level Homo sapiens
-
additional information no expression in placenta Homo sapiens
-
additional information no expression in skeletal muscle Mus musculus
-
pancreas minimal expression Homo sapiens
-
skeletal muscle high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis Mus musculus ?
-
?
additional information high QR2 activity might make individuals more susceptible to Parkinson‘s disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite Homo sapiens ?
-
?
additional information enzyme cannot use NADH or NADPH as reducing agent Homo sapiens ?
-
?
N-benzyldihydronicotinamide + menadione
-
Mus musculus ?
-
?
N-methyldihydronicotinamide + menadione
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NRH:quinone reductase 2
-
Mus musculus
NRH:quinone reductase 2
-
Homo sapiens
QR2
-
Mus musculus
QR2
-
Homo sapiens
quinone reductase 2
-
Mus musculus
quinone reductase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD contains 1 FAD per monomer firmly bound to the enzyme through multiple interactions Homo sapiens
additional information enzyme cannot use NADH or NADPH as reducing agent Homo sapiens