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Literature summary for 1.10.3.11 extracted from
- Expression of the alternative oxidase influences jun N-terminal kinase signaling and cell migration (2018), Mol. Cell. Biol., 38, e00110-18 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ciona intestinalis | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AOX | - |
Ciona intestinalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | expression of alternative oxidase (AOX) is able to promote cell migratory behavior in two different models: in Drosophila, AOX expression corrects thoracic closure defects produced by impaired signaling at several steps in the JNK pathway, while AOX-expressing immortalized mouse embryonic fibroblasts but not primary mouse embryonic fibroblasts show enhanced migration, which is abolished by JNK inhibitor V. AOX was unable to correct cell migration defects resulting from downregulation of the main JNK substrate, the c-Jun subunit of AP-1, or by manipulation of other factors, such as the AP-1 downstream target puc or the pnr transcription factor | Ciona intestinalis |
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Release 2023.1 (January 2023)
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