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Literature summary for 1.10.3.11 extracted from
- Comparison of the kinetic parameters of alternative oxidases from Trypanosoma brucei and Arabidopsis thaliana-A tale of two cavities (2021), Front. Plant Sci., 12, 744218 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in the Escherichia coli DELTAhemA mutant FN102 | Trypanosoma brucei brucei |
| expression in the Escherichia coli DELTAhemA mutant FN102 | Arabidopsis thaliana |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ascochlorin | - |
Arabidopsis thaliana | |
| ascochlorin | - |
Trypanosoma brucei brucei | |
| ascofuranone | - |
Trypanosoma brucei brucei |  |
| colletochlorin | - |
Trypanosoma brucei brucei | |
| colletochlorin D | - |
Trypanosoma brucei brucei | |
| octylgallate | weak inhibition | Arabidopsis thaliana | |
| octylgallate | weak inhibition | Trypanosoma brucei brucei | |
| Salicylhydroxamic acid | weak inhibition | Arabidopsis thaliana | |
| Salicylhydroxamic acid | weak inhibition | Trypanosoma brucei brucei | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00115 | - |
O2 | pH 7.5, 25°C | Trypanosoma brucei brucei | |
| 0.00241 | - |
O2 | pH 7.5, 25°C | Arabidopsis thaliana | |
| 0.026 | - |
ubiquinol-1 | pH 7.5, 25°C | Arabidopsis thaliana | |
| 0.451 | - |
ubiquinol-1 | pH 7.5, 25°C | Trypanosoma brucei brucei | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ubiquinol-1 + O2 | Trypanosoma brucei brucei | - |
2 ubiquinone-1 + 2 H2O | - |
? | |
| 2 ubiquinol-1 + O2 | Arabidopsis thaliana | - |
2 ubiquinone-1 + 2 H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q39219 | - |
- |
| Trypanosoma brucei brucei | Q26710 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Trypanosoma brucei brucei |
- |
Arabidopsis thaliana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ubiquinol-1 + O2 | - |
Trypanosoma brucei brucei | 2 ubiquinone-1 + 2 H2O | - |
? | |
| 2 ubiquinol-1 + O2 | - |
Arabidopsis thaliana | 2 ubiquinone-1 + 2 H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alternative oxidases | - |
Trypanosoma brucei brucei |
| alternative oxidases | - |
Arabidopsis thaliana |
| AtAOX1A | - |
Arabidopsis thaliana |
| TAOX | - |
Trypanosoma brucei brucei |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000013 | - |
pH 7.5, 25°C | Trypanosoma brucei brucei | ascofuranone | |
| 0.0000025 | - |
pH 7.5, 25°C | Trypanosoma brucei brucei | colletochlorin | |
| 0.0000037 | - |
pH 7.5, 25°C | Trypanosoma brucei brucei | ascochlorin | |
| 0.0000038 | - |
pH 7.5, 25°C | Trypanosoma brucei brucei | colletochlorin D | |
| 0.0000147 | - |
pH 7.5, 25°C | Arabidopsis thaliana | ascochlorin |
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