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Literature summary for 1.10.3.1 extracted from

  • Kim, Y.J.; Uyama, H.
    Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future (2005), Cell. Mol. Life Sci., 62, 1707-1723.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for development of specific inhibitors to avoid unfavorable enzymatic browning of plant-derived foods by tyrosinase causing decrease in nutritional quality and economic loss of food products Beta vulgaris
nutrition the enzyme is a target for development of specific inhibitors to avoid unfavorable enzymatic browning of plant-derived foods by tyrosinase causing decrease in nutritional quality and economic loss of food products Beta vulgaris

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin
-
Agaricus bisporus
(-)-epigallocatechin
-
Beta vulgaris
(-)-epigallocatechin
-
Homo sapiens
(-)-epigallocatechin
-
Neurospora crassa
(-)-epigallocatechin
-
Streptomyces glaucescens
(-)-epigallocatechin-3-O-gallate
-
Agaricus bisporus
(-)-epigallocatechin-3-O-gallate
-
Beta vulgaris
(-)-epigallocatechin-3-O-gallate
-
Homo sapiens
(-)-epigallocatechin-3-O-gallate
-
Neurospora crassa
(-)-epigallocatechin-3-O-gallate
-
Streptomyces glaucescens
(R)-HTCCA
-
Agaricus bisporus
(R)-HTCCA
-
Beta vulgaris
(R)-HTCCA
-
Homo sapiens
(R)-HTCCA
-
Neurospora crassa
(R)-HTCCA
-
Streptomyces glaucescens
(S)-HTCCA
-
Agaricus bisporus
(S)-HTCCA
-
Beta vulgaris
(S)-HTCCA
-
Homo sapiens
(S)-HTCCA
-
Neurospora crassa
(S)-HTCCA
-
Streptomyces glaucescens
4-hexylresorcinol
-
Agaricus bisporus
4-hexylresorcinol
-
Beta vulgaris
4-hexylresorcinol
-
Homo sapiens
4-hexylresorcinol
-
Neurospora crassa
4-hexylresorcinol
-
Streptomyces glaucescens
aloesin
-
Agaricus bisporus
aloesin
-
Beta vulgaris
aloesin
-
Homo sapiens
aloesin
-
Neurospora crassa
aloesin
-
Streptomyces glaucescens
Anisaldehyde noncompetitive, IC50: 0.320 mM Agaricus bisporus
Anisaldehyde noncompetitive, IC50: 0.320 mM Beta vulgaris
Anisaldehyde noncompetitive, IC50: 0.320 mM Homo sapiens
Anisaldehyde noncompetitive, IC50: 0.320 mM Neurospora crassa
Anisaldehyde noncompetitive, IC50: 0.320 mM Streptomyces glaucescens
ascorbic acid inhibition of tyrosinase-catalyzed enzymatic browning by trapping the dopaquinone intermediate with cysteine or ascorbic acid, overview Beta vulgaris
azelaic acid
-
Agaricus bisporus
azelaic acid
-
Beta vulgaris
azelaic acid
-
Homo sapiens
azelaic acid
-
Neurospora crassa
azelaic acid
-
Streptomyces glaucescens
captopril
-
Agaricus bisporus
captopril
-
Beta vulgaris
captopril
-
Homo sapiens
captopril
-
Neurospora crassa
captopril
-
Streptomyces glaucescens
cinnamaldehyde noncompetitive, 0.980 mM Agaricus bisporus
cinnamaldehyde noncompetitive, 0.980 mM Beta vulgaris
cinnamaldehyde noncompetitive, 0.980 mM Homo sapiens
cinnamaldehyde noncompetitive, 0.980 mM Neurospora crassa
cinnamaldehyde noncompetitive, 0.980 mM Streptomyces glaucescens
cuminaldehyde noncompetitive, IC50: 0.050 mM Agaricus bisporus
cuminaldehyde noncompetitive, IC50: 0.050 mM Beta vulgaris
cuminaldehyde noncompetitive, IC50: 0.050 mM Homo sapiens
cuminaldehyde noncompetitive, IC50: 0.050 mM Neurospora crassa
cuminaldehyde noncompetitive, IC50: 0.050 mM Streptomyces glaucescens
Cupferron
-
Agaricus bisporus
Cupferron
-
Beta vulgaris
Cupferron
-
Homo sapiens
Cupferron
-
Neurospora crassa
Cupferron
-
Streptomyces glaucescens
cysteine inhibition of tyrosinase-catalyzed enzymatic browning by trapping the dopaquinone intermediate with cysteine or ascorbic acid, overview Beta vulgaris
davanol
-
Agaricus bisporus
davanol
-
Beta vulgaris
davanol
-
Homo sapiens
davanol
-
Neurospora crassa
davanol
-
Streptomyces glaucescens
decahydro-2-naphthyl gallate
-
Agaricus bisporus
decahydro-2-naphthyl gallate
-
Beta vulgaris
decahydro-2-naphthyl gallate
-
Homo sapiens
decahydro-2-naphthyl gallate
-
Neurospora crassa
decahydro-2-naphthyl gallate
-
Streptomyces glaucescens
dopastin
-
Agaricus bisporus
dopastin
-
Beta vulgaris
dopastin
-
Homo sapiens
dopastin
-
Neurospora crassa
dopastin
-
Streptomyces glaucescens
geranyl gallate
-
Agaricus bisporus
geranyl gallate
-
Beta vulgaris
geranyl gallate
-
Homo sapiens
geranyl gallate
-
Neurospora crassa
geranyl gallate
-
Streptomyces glaucescens
glabrene mixed-type, IC50: 7.600 mM Agaricus bisporus
glabrene mixed-type, IC50: 7.600 mM Beta vulgaris
glabrene mixed-type, IC50: 7.600 mM Homo sapiens
glabrene mixed-type, IC50: 7.600 mM Neurospora crassa
glabrene mixed-type, IC50: 7.600 mM Streptomyces glaucescens
glabridin noncompetitive, IC50: 0.004 mM Agaricus bisporus
glabridin noncompetitive, IC50: 0.004 mM Beta vulgaris
glabridin noncompetitive, IC50: 0.004 mM Homo sapiens
glabridin noncompetitive, IC50: 0.004 mM Neurospora crassa
glabridin noncompetitive, IC50: 0.004 mM Streptomyces glaucescens
isoliquiritigenin mixed-type, IC50: 0.047 Agaricus bisporus
isoliquiritigenin mixed-type, IC50: 0.047 Beta vulgaris
isoliquiritigenin mixed-type, IC50: 0.047 Homo sapiens
isoliquiritigenin mixed-type, IC50: 0.047 Neurospora crassa
isoliquiritigenin mixed-type, IC50: 0.047 Streptomyces glaucescens
kaempferol
-
Agaricus bisporus
kaempferol
-
Beta vulgaris
kaempferol
-
Homo sapiens
kaempferol
-
Neurospora crassa
kaempferol
-
Streptomyces glaucescens
kojic acid mixed-type, IC50: 0.014 mM Agaricus bisporus
kojic acid mixed-type, IC50: 0.014 mM Beta vulgaris
kojic acid mixed-type, IC50: 0.014 mM Homo sapiens
kojic acid mixed-type, IC50: 0.014 mM Neurospora crassa
kojic acid mixed-type, IC50: 0.014 mM Streptomyces glaucescens
L-mimosine
-
Agaricus bisporus
L-mimosine
-
Beta vulgaris
L-mimosine
-
Homo sapiens
L-mimosine
-
Neurospora crassa
L-mimosine
-
Streptomyces glaucescens
luteolin noncompetitive, IC50: 0.190 mM Agaricus bisporus
luteolin noncompetitive, IC50: 0.190 mM Beta vulgaris
luteolin noncompetitive, IC50: 0.190 mM Homo sapiens
luteolin noncompetitive, IC50: 0.190 mM Neurospora crassa
luteolin noncompetitive, IC50: 0.190 mM Streptomyces glaucescens
luteolin 7-O-glucoside noncompetitive, IC50: 0.500 mM Agaricus bisporus
luteolin 7-O-glucoside noncompetitive, IC50: 0.500 mM Beta vulgaris
luteolin 7-O-glucoside noncompetitive, IC50: 0.500 mM Homo sapiens
luteolin 7-O-glucoside noncompetitive, IC50: 0.500 mM Neurospora crassa
luteolin 7-O-glucoside noncompetitive, IC50: 0.500 mM Streptomyces glaucescens
Methimazole
-
Agaricus bisporus
Methimazole
-
Beta vulgaris
Methimazole
-
Homo sapiens
Methimazole
-
Neurospora crassa
Methimazole
-
Streptomyces glaucescens
additional information structure, application and importance of inhibitors, overview Agaricus bisporus
additional information structure, application and importance of inhibitors, overview Beta vulgaris
additional information melanin plays a crucial protective role against skin photocarcinogenesis, however, the production of abnormal melanin pigmentation is a serious esthetic problem in humans, melanin biosynthesis can be inhibited by avoiding UV exposure, the inhibition of tyrosinase, the inhibition of melanocyte metabolism and proliferation, or the removal of melanin with corneal ablation, overview, structure, application and importance of inhibitors, overview Homo sapiens
additional information structure, application and importance of inhibitors, overview Neurospora crassa
additional information structure, application and importance of inhibitors, overview Streptomyces glaucescens
morin
-
Agaricus bisporus
morin competitive, IC50: 2.320 mM Beta vulgaris
morin
-
Homo sapiens
morin
-
Neurospora crassa
morin
-
Streptomyces glaucescens
quercetin
-
Agaricus bisporus
quercetin
-
Beta vulgaris
quercetin
-
Homo sapiens
quercetin
-
Neurospora crassa
quercetin
-
Streptomyces glaucescens
tropolone
-
Agaricus bisporus
tropolone
-
Beta vulgaris
tropolone
-
Homo sapiens
tropolone
-
Neurospora crassa
tropolone
-
Streptomyces glaucescens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ bound to the enzyme, presently available for any tyrosinases, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers Streptomyces glaucescens
Cu2+ bound to the enzyme, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers Beta vulgaris
Cu2+ bound to the enzyme, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers Homo sapiens
Cu2+ bound to the enzyme, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers Neurospora crassa
Cu2+ bound to the enzyme, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers Agaricus bisporus
H2O2 the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer Beta vulgaris
H2O2 the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer Homo sapiens
H2O2 the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer Neurospora crassa
H2O2 the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer Agaricus bisporus
H2O2 the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer Streptomyces glaucescens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30900
-
1 * 30900 Streptomyces glaucescens
40000
-
1 * 40000 Beta vulgaris
43000
-
2 * 134000 + 2 * 43000, alpha2beta2 subunit composition Agaricus bisporus
46000
-
1 * 46000 Neurospora crassa
66700
-
1 * 66700 Homo sapiens
134000
-
2 * 134000 + 2 * 43000, alpha2beta2 subunit composition Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4,5-trihydroxy-L-phenylalanine + O2 Homo sapiens cytotoxicity of TOPA ?
-
?
chlorogenic acid + O2 Beta vulgaris formation of a highly reactive o-quinone intermediate which then could interact with NH2 groups of lysine, SCH3 groups of methionines and indole rings of tryptophan in nucleophilic addition and in polymerization reactions, the so-called browning and greening reactions ?
-
?
L-tyrosine + L-dopa + O2 Beta vulgaris
-
L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2 Neurospora crassa
-
L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2 Agaricus bisporus
-
L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2 Streptomyces glaucescens
-
L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2 Homo sapiens pathway of melanin biosynthesis, detailed overview L-dopa + dopaquinone + H2O cytotoxicity of L-DOPA ?
additional information Homo sapiens tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair, various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation ?
-
?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-
Beta vulgaris
-
spinach-beet
-
Homo sapiens
-
-
-
Neurospora crassa
-
-
-
Streptomyces glaucescens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 13% carbohydrate Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4,5-trihydroxy-L-phenylalanine + O2 cytotoxicity of TOPA Homo sapiens ?
-
?
3,4,5-trihydroxy-L-phenylalanine + O2 i.e. TOPA Homo sapiens ?
-
?
chlorogenic acid + O2 formation of a highly reactive o-quinone intermediate which then could interact with NH2 groups of lysine, SCH3 groups of methionines and indole rings of tryptophan in nucleophilic addition and in polymerization reactions, the so-called browning and greening reactions Beta vulgaris ?
-
?
chlorogenic acid + O2 formation of a highly reactive o-quinone intermediate Beta vulgaris ?
-
?
L-tyrosine + L-dopa + O2
-
Beta vulgaris L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2
-
Neurospora crassa L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2
-
Agaricus bisporus L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2
-
Streptomyces glaucescens L-dopa + dopaquinone + H2O
-
?
L-tyrosine + L-dopa + O2
-
Beta vulgaris L-dopa + dopaquinone + H2O o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome ?
L-tyrosine + L-dopa + O2
-
Homo sapiens L-dopa + dopaquinone + H2O o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome ?
L-tyrosine + L-dopa + O2
-
Neurospora crassa L-dopa + dopaquinone + H2O o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome ?
L-tyrosine + L-dopa + O2
-
Agaricus bisporus L-dopa + dopaquinone + H2O o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome ?
L-tyrosine + L-dopa + O2
-
Streptomyces glaucescens L-dopa + dopaquinone + H2O o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome ?
L-tyrosine + L-dopa + O2 pathway of melanin biosynthesis, detailed overview Homo sapiens L-dopa + dopaquinone + H2O cytotoxicity of L-DOPA ?
additional information tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair, various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation Homo sapiens ?
-
?
additional information tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action Beta vulgaris ?
-
?
additional information tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action Homo sapiens ?
-
?
additional information tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action Neurospora crassa ?
-
?
additional information tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action Agaricus bisporus ?
-
?
additional information tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action Streptomyces glaucescens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 40000 Beta vulgaris
monomer 1 * 46000 Neurospora crassa
monomer 1 * 30900 Streptomyces glaucescens
monomer 1 * 66700 Homo sapiens
tetramer 2 * 134000 + 2 * 43000, alpha2beta2 subunit composition Agaricus bisporus

Synonyms

Synonyms Comment Organism
diphenolase
-
Beta vulgaris
diphenolase
-
Homo sapiens
diphenolase
-
Neurospora crassa
diphenolase
-
Agaricus bisporus
diphenolase
-
Streptomyces glaucescens
tyrosinase
-
Beta vulgaris
tyrosinase
-
Homo sapiens
tyrosinase
-
Neurospora crassa
tyrosinase
-
Agaricus bisporus
tyrosinase
-
Streptomyces glaucescens

Cofactor

Cofactor Comment Organism Structure
additional information if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial Beta vulgaris
additional information if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial Homo sapiens
additional information if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial Neurospora crassa
additional information if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial Agaricus bisporus
additional information if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial Streptomyces glaucescens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.004
-
noncompetitive, IC50: 0.004 mM Beta vulgaris glabridin
0.004
-
noncompetitive, IC50: 0.004 mM Homo sapiens glabridin
0.004
-
noncompetitive, IC50: 0.004 mM Neurospora crassa glabridin
0.004
-
noncompetitive, IC50: 0.004 mM Agaricus bisporus glabridin
0.004
-
noncompetitive, IC50: 0.004 mM Streptomyces glaucescens glabridin
0.014
-
mixed-type, IC50: 0.014 mM Beta vulgaris kojic acid
0.014
-
mixed-type, IC50: 0.014 mM Homo sapiens kojic acid
0.014
-
mixed-type, IC50: 0.014 mM Neurospora crassa kojic acid
0.014
-
mixed-type, IC50: 0.014 mM Agaricus bisporus kojic acid
0.014
-
mixed-type, IC50: 0.014 mM Streptomyces glaucescens kojic acid
0.047
-
mixed-type, IC50: 0.047 mM Beta vulgaris isoliquiritigenin
0.047
-
mixed-type, IC50: 0.047 mM Neurospora crassa isoliquiritigenin
0.047
-
mixed-type, IC50: 0.047 mM Agaricus bisporus isoliquiritigenin
0.047
-
mixed-type, IC50: 0.047 mM Streptomyces glaucescens isoliquiritigenin
0.05
-
noncompetitive, IC50: 0.050 mM Beta vulgaris cuminaldehyde
0.05
-
noncompetitive, IC50: 0.050 mM Homo sapiens cuminaldehyde
0.05
-
noncompetitive, IC50: 0.050 mM Neurospora crassa cuminaldehyde
0.05
-
noncompetitive, IC50: 0.050 mM Agaricus bisporus cuminaldehyde
0.05
-
noncompetitive, IC50: 0.050 mM Streptomyces glaucescens cuminaldehyde
0.19
-
noncompetitive, IC50: 0.190 mM Beta vulgaris luteolin
0.19
-
noncompetitive, IC50: 0.190 mM Homo sapiens luteolin
0.19
-
noncompetitive, IC50: 0.190 mM Neurospora crassa luteolin
0.19
-
noncompetitive, IC50: 0.190 mM Agaricus bisporus luteolin
0.19
-
noncompetitive, IC50: 0.190 mM Streptomyces glaucescens luteolin
0.32
-
noncompetitive, IC50: 0.320 mM Beta vulgaris Anisaldehyde
0.32
-
noncompetitive, IC50: 0.320 mM Homo sapiens Anisaldehyde
0.32
-
noncompetitive, IC50: 0.320 mM Neurospora crassa Anisaldehyde
0.32
-
noncompetitive, IC50: 0.320 mM Agaricus bisporus Anisaldehyde
0.32
-
noncompetitive, IC50: 0.320 mM Streptomyces glaucescens Anisaldehyde
0.5
-
noncompetitive, IC50: 0.500 mM Beta vulgaris luteolin 7-O-glucoside
0.5
-
noncompetitive, IC50: 0.500 mM Homo sapiens luteolin 7-O-glucoside
0.5
-
noncompetitive, IC50: 0.500 mM Neurospora crassa luteolin 7-O-glucoside
0.5
-
noncompetitive, IC50: 0.500 mM Agaricus bisporus luteolin 7-O-glucoside
0.5
-
noncompetitive, IC50: 0.500 mM Streptomyces glaucescens luteolin 7-O-glucoside
2.32
-
competitive, IC50: 2.320 mM Beta vulgaris morin
7.6
-
mixed-type, IC50: 7.600 mM Beta vulgaris glabrene
7.6
-
mixed-type, IC50: 7.600 mM Homo sapiens glabrene
7.6
-
mixed-type, IC50: 7.600 mM Neurospora crassa glabrene
7.6
-
mixed-type, IC50: 7.600 mM Agaricus bisporus glabrene
7.6
-
mixed-type, IC50: 7.600 mM Streptomyces glaucescens glabrene