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Literature summary for 1.1.98.7 extracted from

  • Marquordt, C.; Fang, Q.; Will, E.; Peng, J.; von Figura, K.; Dierks, T.
    Posttranslational modification of serine to formylglycine in bacterial sulfatases. Recognition of the modification motif by the iron-sulfur protein AtsB (2002), J. Biol. Chem., 278, 2212-2218 .
    View publication on PubMed
Search for more literature for 1.1.98.7

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Klebsiella pneumoniae 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine Klebsiella pneumoniae the enzyme is strictly required for modification of Ser72 in the periplasmic sulfatase AtsA of Klebsiella pneumoniae. AtsB-mediated formation of 3-oxo-L-alanine is dependent on the signal peptide of AtsA [periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae Q9X758
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [sulfatase]-L-serine AtsB from Klebsiella pneumoniae can act on sulfatases of other species. The cytosolic cysteine-type sulfatase of Pseudomonas aeruginosa can be converted into a substrate of Klebsiella pneumoniae AtsB if the cysteine is substituted by serine and a signal peptide is added Klebsiella pneumoniae [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine the enzyme is strictly required for modification of Ser72 in the periplasmic sulfatase AtsA of Klebsiella pneumoniae. AtsB-mediated formation of 3-oxo-L-alanine is dependent on the signal peptide of AtsA Klebsiella pneumoniae [periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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 ?
S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine AtsB-mediated formation of 3-oxo-L-alanine is dependent on the signal peptide of AtsA. AtsB physically interacts with AtsA in a Ser72-dependent manner Klebsiella pneumoniae [periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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Synonyms

Synonyms Comment Organism
AtsB
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 Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
iron-sulfur centre
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 Klebsiella pneumoniae

General Information

General Information Comment Organism
metabolism the enzyme is strictly required for modification of Ser72 in the periplasmic sulfatase AtsA of Klebsiella pneumoniae Klebsiella pneumoniae