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Literature summary for 1.1.98.3 extracted from

  • Trefzer, C.; Skovierova, H.; Buroni, S.; Bobovska, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.; Makarov, V.; Cole, S.; Riccardi, G.; Mikusova, K.; Johnsson, K.
    Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1 (2012), J. Am. Chem. Soc., 134, 912-915.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycolicibacterium smegmatis

Protein Variants

Protein Variants Comment Organism
C394G benzothiazinone-resistant mutant, reduces benzothiazinones to inert metabolites while avoiding covalent inactivation Mycolicibacterium smegmatis
C394S benzothiazinone-resistant mutant, reduces benzothiazinones to inert metabolites while avoiding covalent inactivation Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one i.e. BTZ043, inhibits enzyme by formation of a semimercaptal Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R607
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2Z,6E)-farnesylphosphoryl-beta-D-ribofuranose + FAD
-
Mycolicibacterium smegmatis (2Z,6E)-farnesylphosphoryl-D-beta-D-erythro-pentofuranosid-2-ulose + FADH2 oxidation reaction calyzed by decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1 ?
additional information decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase is constituted of decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1 and decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase DprE2 that together catalyze the epimerization of decaprenylphosphoryl-beta-D-ribofuranose to decaprenylphosphoryl-beta-D-arabinofuranose Mycolicibacterium smegmatis ?
-
?
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD
-
Mycolicibacterium smegmatis trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 oxidation reaction catalyzed by decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1 ?

Synonyms

Synonyms Comment Organism
DprE1
-
Mycolicibacterium smegmatis
MSMEG_6382
-
Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mycolicibacterium smegmatis

General Information

General Information Comment Organism
physiological function decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase is constituted of DprE1 and DprE2 that together catalyze the epimerization of decaprenylphosphoryl-beta-D-ribofuranose to decaprenylphosphoryl-beta-D-arabinofuranose Mycolicibacterium smegmatis