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Literature summary for 1.1.5.4 extracted from
- Disruption of malate:quinone oxidoreductase increases L-lysine production by Corynebacterium glutamicum (2006), Biosci. Biotechnol. Biochem., 70, 2803-2806.
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | the disruption of the mqo gene results in increased L-lysine production. The mutation supports industrial levels of L-lysine production in Corynebacterium glutamicum | Corynebacterium glutamicum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Corynebacterium glutamicum | the loss of malate:quinone oxidoreductase activity down-regulates the flux of the tricarboxylic acid cycle to maintain the redox balance and results in redirection of oxaloacetate into L-lysine biosynthesis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium glutamicum | - |
the L-lysine-producing mutant, Corynebacterium glutamicum B-6 carries a nonsense mutation in the mqo gene | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the loss of malate:quinone oxidoreductase activity down-regulates the flux of the tricarboxylic acid cycle to maintain the redox balance and results in redirection of oxaloacetate into L-lysine biosynthesis | Corynebacterium glutamicum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| malate:quinone oxidoreductase | - |
Corynebacterium glutamicum |
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