Application | Comment | Organism |
---|---|---|
medicine | lower enzyme expression is associated with tumor progression and/or worsened prognosis in patients with renal cell carcinoma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-hydroxyglutarate + a quinone | Homo sapiens | - |
2-oxoglutarate + a quinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
769-P cell | - |
Homo sapiens | - |
A-498 cell | - |
Homo sapiens | - |
A-498 cell | mutation A241G in A498 cells | Homo sapiens | - |
Caki-1 cell | - |
Homo sapiens | - |
OS-RC-2 cell | - |
Homo sapiens | - |
renal cell carcinoma cell | - |
Homo sapiens | - |
RXF-393 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-hydroxyglutarate + a quinone | - |
Homo sapiens | 2-oxoglutarate + a quinol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-2-HG dehydrogenase | - |
Homo sapiens |
L-2-hydroxyglutarate dehydrogenase | - |
Homo sapiens |
L2HGDH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme suppresses both in vitro cell migration and in vivo tumor growth in renal cell carcinoma | Homo sapiens |