Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.5.13 extracted from

  • Shelar, S.; Shim, E.H.; Brinkley, G.J.; Kundu, A.; Carobbio, F.; Poston, T.; Tan, J.; Parekh, V.; Benson, D.; Crossman, D.K.; Buckhaults, P.J.; Rakheja, D.; Kirkman, R.; Sato, Y.; Ogawa, S.; Dutta, S.; Velu, S.E.; Emberley, E.; Pan, A.; Chen, J.; Huang, T.; Absher, D.; Becker, A.; Kunick, C.; Sudarshan, S.
    Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer (2018), Clin. Cancer Res., 24, 6433-6446 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine lower enzyme expression is associated with tumor progression and/or worsened prognosis in patients with renal cell carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-2-hydroxyglutarate + a quinone Homo sapiens
-
2-oxoglutarate + a quinol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
769-P cell
-
Homo sapiens
-
A-498 cell
-
Homo sapiens
-
A-498 cell mutation A241G in A498 cells Homo sapiens
-
Caki-1 cell
-
Homo sapiens
-
OS-RC-2 cell
-
Homo sapiens
-
renal cell carcinoma cell
-
Homo sapiens
-
RXF-393 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-hydroxyglutarate + a quinone
-
Homo sapiens 2-oxoglutarate + a quinol
-
?

Synonyms

Synonyms Comment Organism
L-2-HG dehydrogenase
-
Homo sapiens
L-2-hydroxyglutarate dehydrogenase
-
Homo sapiens
L2HGDH
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme suppresses both in vitro cell migration and in vivo tumor growth in renal cell carcinoma Homo sapiens